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Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda

Micronutrient deficiencies and stunting are prevalent. We assessed correlates of iron, cobalamin, folate, and vitamin A biomarkers in a cross-sectional study of stunted children aged 12–59 months in eastern Uganda. The biomarkers measured were serum ferritin (S-FE), soluble transferrin receptor (S-T...

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Autores principales: Mutumba, Rolland, Pesu, Hannah, Mbabazi, Joseph, Greibe, Eva, Olsen, Mette F., Briend, André, Mølgaard, Christian, Ritz, Christian, Nabukeera-Barungi, Nicolette, Mupere, Ezekiel, Filteau, Suzanne, Friis, Henrik, Grenov, Benedikte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421162/
https://www.ncbi.nlm.nih.gov/pubmed/37571364
http://dx.doi.org/10.3390/nu15153429
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author Mutumba, Rolland
Pesu, Hannah
Mbabazi, Joseph
Greibe, Eva
Olsen, Mette F.
Briend, André
Mølgaard, Christian
Ritz, Christian
Nabukeera-Barungi, Nicolette
Mupere, Ezekiel
Filteau, Suzanne
Friis, Henrik
Grenov, Benedikte
author_facet Mutumba, Rolland
Pesu, Hannah
Mbabazi, Joseph
Greibe, Eva
Olsen, Mette F.
Briend, André
Mølgaard, Christian
Ritz, Christian
Nabukeera-Barungi, Nicolette
Mupere, Ezekiel
Filteau, Suzanne
Friis, Henrik
Grenov, Benedikte
author_sort Mutumba, Rolland
collection PubMed
description Micronutrient deficiencies and stunting are prevalent. We assessed correlates of iron, cobalamin, folate, and vitamin A biomarkers in a cross-sectional study of stunted children aged 12–59 months in eastern Uganda. The biomarkers measured were serum ferritin (S-FE), soluble transferrin receptor (S-TfR), retinol binding protein (S-RBP), plasma cobalamin (P-Cob), methylmalonic acid (P-MMA), and folate (P-Fol). Using linear regression, we assessed socio-demography, stunting severity, malaria rapid test, and inflammation as correlates of micronutrient biomarkers. Of the 750 children, the mean (SD) age was 32.0 (11.7) months, and 45% were girls. Iron stores were depleted (inflammation-corrected S-FE < 12 µg/L) in 43%, and 62% had tissue iron deficiency (S-TfR > 8.3 mg/L). P-Cob was low (<148 pmol/L) and marginal (148–221 pmol/L) in 3% and 20%, and 16% had high P-MMA (>0.75 µmol/L). Inflammation-corrected S-RBP was low (<0.7 µmol/L) in 21% and P-Fol (<14 nmol/L) in 1%. Age 24–59 months was associated with higher S-FE and P-Fol and lower S-TfR. Breastfeeding beyond infancy was associated with lower iron status and cobalamin status, and malaria was associated with lower cobalamin status and tissue iron deficiency (higher S-TfR) despite iron sequestration in stores (higher S-FE). In conclusion, stunted children have iron, cobalamin, and vitamin A deficiencies. Interventions addressing stunting should target co-existing micronutrient deficiencies.
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spelling pubmed-104211622023-08-12 Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda Mutumba, Rolland Pesu, Hannah Mbabazi, Joseph Greibe, Eva Olsen, Mette F. Briend, André Mølgaard, Christian Ritz, Christian Nabukeera-Barungi, Nicolette Mupere, Ezekiel Filteau, Suzanne Friis, Henrik Grenov, Benedikte Nutrients Article Micronutrient deficiencies and stunting are prevalent. We assessed correlates of iron, cobalamin, folate, and vitamin A biomarkers in a cross-sectional study of stunted children aged 12–59 months in eastern Uganda. The biomarkers measured were serum ferritin (S-FE), soluble transferrin receptor (S-TfR), retinol binding protein (S-RBP), plasma cobalamin (P-Cob), methylmalonic acid (P-MMA), and folate (P-Fol). Using linear regression, we assessed socio-demography, stunting severity, malaria rapid test, and inflammation as correlates of micronutrient biomarkers. Of the 750 children, the mean (SD) age was 32.0 (11.7) months, and 45% were girls. Iron stores were depleted (inflammation-corrected S-FE < 12 µg/L) in 43%, and 62% had tissue iron deficiency (S-TfR > 8.3 mg/L). P-Cob was low (<148 pmol/L) and marginal (148–221 pmol/L) in 3% and 20%, and 16% had high P-MMA (>0.75 µmol/L). Inflammation-corrected S-RBP was low (<0.7 µmol/L) in 21% and P-Fol (<14 nmol/L) in 1%. Age 24–59 months was associated with higher S-FE and P-Fol and lower S-TfR. Breastfeeding beyond infancy was associated with lower iron status and cobalamin status, and malaria was associated with lower cobalamin status and tissue iron deficiency (higher S-TfR) despite iron sequestration in stores (higher S-FE). In conclusion, stunted children have iron, cobalamin, and vitamin A deficiencies. Interventions addressing stunting should target co-existing micronutrient deficiencies. MDPI 2023-08-02 /pmc/articles/PMC10421162/ /pubmed/37571364 http://dx.doi.org/10.3390/nu15153429 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mutumba, Rolland
Pesu, Hannah
Mbabazi, Joseph
Greibe, Eva
Olsen, Mette F.
Briend, André
Mølgaard, Christian
Ritz, Christian
Nabukeera-Barungi, Nicolette
Mupere, Ezekiel
Filteau, Suzanne
Friis, Henrik
Grenov, Benedikte
Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda
title Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda
title_full Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda
title_fullStr Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda
title_full_unstemmed Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda
title_short Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda
title_sort correlates of iron, cobalamin, folate, and vitamin a status among stunted children: a cross-sectional study in uganda
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421162/
https://www.ncbi.nlm.nih.gov/pubmed/37571364
http://dx.doi.org/10.3390/nu15153429
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