Cargando…
Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda
Micronutrient deficiencies and stunting are prevalent. We assessed correlates of iron, cobalamin, folate, and vitamin A biomarkers in a cross-sectional study of stunted children aged 12–59 months in eastern Uganda. The biomarkers measured were serum ferritin (S-FE), soluble transferrin receptor (S-T...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421162/ https://www.ncbi.nlm.nih.gov/pubmed/37571364 http://dx.doi.org/10.3390/nu15153429 |
_version_ | 1785088903525433344 |
---|---|
author | Mutumba, Rolland Pesu, Hannah Mbabazi, Joseph Greibe, Eva Olsen, Mette F. Briend, André Mølgaard, Christian Ritz, Christian Nabukeera-Barungi, Nicolette Mupere, Ezekiel Filteau, Suzanne Friis, Henrik Grenov, Benedikte |
author_facet | Mutumba, Rolland Pesu, Hannah Mbabazi, Joseph Greibe, Eva Olsen, Mette F. Briend, André Mølgaard, Christian Ritz, Christian Nabukeera-Barungi, Nicolette Mupere, Ezekiel Filteau, Suzanne Friis, Henrik Grenov, Benedikte |
author_sort | Mutumba, Rolland |
collection | PubMed |
description | Micronutrient deficiencies and stunting are prevalent. We assessed correlates of iron, cobalamin, folate, and vitamin A biomarkers in a cross-sectional study of stunted children aged 12–59 months in eastern Uganda. The biomarkers measured were serum ferritin (S-FE), soluble transferrin receptor (S-TfR), retinol binding protein (S-RBP), plasma cobalamin (P-Cob), methylmalonic acid (P-MMA), and folate (P-Fol). Using linear regression, we assessed socio-demography, stunting severity, malaria rapid test, and inflammation as correlates of micronutrient biomarkers. Of the 750 children, the mean (SD) age was 32.0 (11.7) months, and 45% were girls. Iron stores were depleted (inflammation-corrected S-FE < 12 µg/L) in 43%, and 62% had tissue iron deficiency (S-TfR > 8.3 mg/L). P-Cob was low (<148 pmol/L) and marginal (148–221 pmol/L) in 3% and 20%, and 16% had high P-MMA (>0.75 µmol/L). Inflammation-corrected S-RBP was low (<0.7 µmol/L) in 21% and P-Fol (<14 nmol/L) in 1%. Age 24–59 months was associated with higher S-FE and P-Fol and lower S-TfR. Breastfeeding beyond infancy was associated with lower iron status and cobalamin status, and malaria was associated with lower cobalamin status and tissue iron deficiency (higher S-TfR) despite iron sequestration in stores (higher S-FE). In conclusion, stunted children have iron, cobalamin, and vitamin A deficiencies. Interventions addressing stunting should target co-existing micronutrient deficiencies. |
format | Online Article Text |
id | pubmed-10421162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104211622023-08-12 Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda Mutumba, Rolland Pesu, Hannah Mbabazi, Joseph Greibe, Eva Olsen, Mette F. Briend, André Mølgaard, Christian Ritz, Christian Nabukeera-Barungi, Nicolette Mupere, Ezekiel Filteau, Suzanne Friis, Henrik Grenov, Benedikte Nutrients Article Micronutrient deficiencies and stunting are prevalent. We assessed correlates of iron, cobalamin, folate, and vitamin A biomarkers in a cross-sectional study of stunted children aged 12–59 months in eastern Uganda. The biomarkers measured were serum ferritin (S-FE), soluble transferrin receptor (S-TfR), retinol binding protein (S-RBP), plasma cobalamin (P-Cob), methylmalonic acid (P-MMA), and folate (P-Fol). Using linear regression, we assessed socio-demography, stunting severity, malaria rapid test, and inflammation as correlates of micronutrient biomarkers. Of the 750 children, the mean (SD) age was 32.0 (11.7) months, and 45% were girls. Iron stores were depleted (inflammation-corrected S-FE < 12 µg/L) in 43%, and 62% had tissue iron deficiency (S-TfR > 8.3 mg/L). P-Cob was low (<148 pmol/L) and marginal (148–221 pmol/L) in 3% and 20%, and 16% had high P-MMA (>0.75 µmol/L). Inflammation-corrected S-RBP was low (<0.7 µmol/L) in 21% and P-Fol (<14 nmol/L) in 1%. Age 24–59 months was associated with higher S-FE and P-Fol and lower S-TfR. Breastfeeding beyond infancy was associated with lower iron status and cobalamin status, and malaria was associated with lower cobalamin status and tissue iron deficiency (higher S-TfR) despite iron sequestration in stores (higher S-FE). In conclusion, stunted children have iron, cobalamin, and vitamin A deficiencies. Interventions addressing stunting should target co-existing micronutrient deficiencies. MDPI 2023-08-02 /pmc/articles/PMC10421162/ /pubmed/37571364 http://dx.doi.org/10.3390/nu15153429 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mutumba, Rolland Pesu, Hannah Mbabazi, Joseph Greibe, Eva Olsen, Mette F. Briend, André Mølgaard, Christian Ritz, Christian Nabukeera-Barungi, Nicolette Mupere, Ezekiel Filteau, Suzanne Friis, Henrik Grenov, Benedikte Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda |
title | Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda |
title_full | Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda |
title_fullStr | Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda |
title_full_unstemmed | Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda |
title_short | Correlates of Iron, Cobalamin, Folate, and Vitamin A Status among Stunted Children: A Cross-Sectional Study in Uganda |
title_sort | correlates of iron, cobalamin, folate, and vitamin a status among stunted children: a cross-sectional study in uganda |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421162/ https://www.ncbi.nlm.nih.gov/pubmed/37571364 http://dx.doi.org/10.3390/nu15153429 |
work_keys_str_mv | AT mutumbarolland correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT pesuhannah correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT mbabazijoseph correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT greibeeva correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT olsenmettef correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT briendandre correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT mølgaardchristian correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT ritzchristian correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT nabukeerabarunginicolette correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT mupereezekiel correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT filteausuzanne correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT friishenrik correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda AT grenovbenedikte correlatesofironcobalaminfolateandvitaminastatusamongstuntedchildrenacrosssectionalstudyinuganda |