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Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate
α-tricalcium (α-TCP) phosphate is widely used as an osteoinductive biocompatible material, serving as an alternative to synthetic porous bone materials. The objective of this study is to obtain a highly filled fibrous nonwoven material composed of poly-3-hydroxybutyrate (PHB) and α-TCP and to invest...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421182/ https://www.ncbi.nlm.nih.gov/pubmed/37571064 http://dx.doi.org/10.3390/polym15153167 |
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author | Tyubaeva, Polina M. Gasparyan, Kristina G. Fedotov, Alexander Yu. Lobzhanidze, Pavel V. Baranov, Oleg V. Egorov, Alexey A. Sirotinkin, Vladimir P. Komlev, Vladimir S. Olkhov, Anatoly A. |
author_facet | Tyubaeva, Polina M. Gasparyan, Kristina G. Fedotov, Alexander Yu. Lobzhanidze, Pavel V. Baranov, Oleg V. Egorov, Alexey A. Sirotinkin, Vladimir P. Komlev, Vladimir S. Olkhov, Anatoly A. |
author_sort | Tyubaeva, Polina M. |
collection | PubMed |
description | α-tricalcium (α-TCP) phosphate is widely used as an osteoinductive biocompatible material, serving as an alternative to synthetic porous bone materials. The objective of this study is to obtain a highly filled fibrous nonwoven material composed of poly-3-hydroxybutyrate (PHB) and α-TCP and to investigate the morphology, structure, and properties of the composite obtained by the electrospinning method (ES). The addition of α-TCP had a significant effect on the supramolecular structure of the material, allowing it to control the crystallinity of the material, which was accompanied by changes in mechanical properties, FTIR spectra, and XRD curves. The obtained results open the way to the creation of new osteoconductive materials with a controlled release of the source of calcium into the living organism. |
format | Online Article Text |
id | pubmed-10421182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104211822023-08-12 Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate Tyubaeva, Polina M. Gasparyan, Kristina G. Fedotov, Alexander Yu. Lobzhanidze, Pavel V. Baranov, Oleg V. Egorov, Alexey A. Sirotinkin, Vladimir P. Komlev, Vladimir S. Olkhov, Anatoly A. Polymers (Basel) Article α-tricalcium (α-TCP) phosphate is widely used as an osteoinductive biocompatible material, serving as an alternative to synthetic porous bone materials. The objective of this study is to obtain a highly filled fibrous nonwoven material composed of poly-3-hydroxybutyrate (PHB) and α-TCP and to investigate the morphology, structure, and properties of the composite obtained by the electrospinning method (ES). The addition of α-TCP had a significant effect on the supramolecular structure of the material, allowing it to control the crystallinity of the material, which was accompanied by changes in mechanical properties, FTIR spectra, and XRD curves. The obtained results open the way to the creation of new osteoconductive materials with a controlled release of the source of calcium into the living organism. MDPI 2023-07-26 /pmc/articles/PMC10421182/ /pubmed/37571064 http://dx.doi.org/10.3390/polym15153167 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tyubaeva, Polina M. Gasparyan, Kristina G. Fedotov, Alexander Yu. Lobzhanidze, Pavel V. Baranov, Oleg V. Egorov, Alexey A. Sirotinkin, Vladimir P. Komlev, Vladimir S. Olkhov, Anatoly A. Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate |
title | Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate |
title_full | Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate |
title_fullStr | Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate |
title_full_unstemmed | Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate |
title_short | Development of Nonwoven Fibrous Materials Based on Poly-3-Hydroxybutyrate with a High Content of α-Tricalcium Phosphate |
title_sort | development of nonwoven fibrous materials based on poly-3-hydroxybutyrate with a high content of α-tricalcium phosphate |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421182/ https://www.ncbi.nlm.nih.gov/pubmed/37571064 http://dx.doi.org/10.3390/polym15153167 |
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