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Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study

The objective is to assess the circulating lipidome of children with obesity before and after lifestyle intervention and to compare the data to the circulating lipidome of adults with obesity before and after bariatric surgery. Ten pediatric (PE) and thirty adult (AD) patients with obesity were pros...

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Autores principales: Soria-Gondek, Andrea, Fernández-García, Pablo, González, Lorena, Reyes-Farias, Marjorie, Murillo, Marta, Valls, Aina, Real, Nativitat, Pellitero, Silvia, Tarascó, Jordi, Jenkins, Benjamin, Galán, María, Villarroya, Francesc, Koulman, Albert, Corrales, Patricia, Vidal-Puig, Antonio, Cereijo, Rubén, Sánchez-Infantes, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421258/
https://www.ncbi.nlm.nih.gov/pubmed/37571279
http://dx.doi.org/10.3390/nu15153341
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author Soria-Gondek, Andrea
Fernández-García, Pablo
González, Lorena
Reyes-Farias, Marjorie
Murillo, Marta
Valls, Aina
Real, Nativitat
Pellitero, Silvia
Tarascó, Jordi
Jenkins, Benjamin
Galán, María
Villarroya, Francesc
Koulman, Albert
Corrales, Patricia
Vidal-Puig, Antonio
Cereijo, Rubén
Sánchez-Infantes, David
author_facet Soria-Gondek, Andrea
Fernández-García, Pablo
González, Lorena
Reyes-Farias, Marjorie
Murillo, Marta
Valls, Aina
Real, Nativitat
Pellitero, Silvia
Tarascó, Jordi
Jenkins, Benjamin
Galán, María
Villarroya, Francesc
Koulman, Albert
Corrales, Patricia
Vidal-Puig, Antonio
Cereijo, Rubén
Sánchez-Infantes, David
author_sort Soria-Gondek, Andrea
collection PubMed
description The objective is to assess the circulating lipidome of children with obesity before and after lifestyle intervention and to compare the data to the circulating lipidome of adults with obesity before and after bariatric surgery. Ten pediatric (PE) and thirty adult (AD) patients with obesity were prospectively recruited at a referral single center. The PE cohort received lifestyle recommendations. The AD cohort underwent bariatric surgery. Clinical parameters and lipidome were analyzed in serum before and after six months of metabolic intervention. The abundance of phosphatidylinositols in the PE cohort and phosphatidylcholines in the AD significantly increased, while O-phosphatidylserines in the PE cohort and diacyl/triacylglycerols in the AD decreased. Fifteen lipid species were coincident in both groups after lifestyle intervention and bariatric surgery. Five species of phosphatidylinositols, sphingomyelins, and cholesteryl esters were upregulated. Eight species of diacylglycerols, glycerophosphoglycerols, glycerophosphoethanolamines, and phosphatidylcholines were downregulated. Most matching species were regulated in the same direction except for two phosphatidylinositols: PI(O-36:2) and PI(O-34:0). A specific set of lipid species regulated after bariatric surgery in adult individuals was also modulated in children undergoing lifestyle intervention, suggesting they may constitute a core circulating lipid profile signature indicative of early development of obesity and improvement after clinical interventions regardless of individual age.
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spelling pubmed-104212582023-08-12 Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study Soria-Gondek, Andrea Fernández-García, Pablo González, Lorena Reyes-Farias, Marjorie Murillo, Marta Valls, Aina Real, Nativitat Pellitero, Silvia Tarascó, Jordi Jenkins, Benjamin Galán, María Villarroya, Francesc Koulman, Albert Corrales, Patricia Vidal-Puig, Antonio Cereijo, Rubén Sánchez-Infantes, David Nutrients Article The objective is to assess the circulating lipidome of children with obesity before and after lifestyle intervention and to compare the data to the circulating lipidome of adults with obesity before and after bariatric surgery. Ten pediatric (PE) and thirty adult (AD) patients with obesity were prospectively recruited at a referral single center. The PE cohort received lifestyle recommendations. The AD cohort underwent bariatric surgery. Clinical parameters and lipidome were analyzed in serum before and after six months of metabolic intervention. The abundance of phosphatidylinositols in the PE cohort and phosphatidylcholines in the AD significantly increased, while O-phosphatidylserines in the PE cohort and diacyl/triacylglycerols in the AD decreased. Fifteen lipid species were coincident in both groups after lifestyle intervention and bariatric surgery. Five species of phosphatidylinositols, sphingomyelins, and cholesteryl esters were upregulated. Eight species of diacylglycerols, glycerophosphoglycerols, glycerophosphoethanolamines, and phosphatidylcholines were downregulated. Most matching species were regulated in the same direction except for two phosphatidylinositols: PI(O-36:2) and PI(O-34:0). A specific set of lipid species regulated after bariatric surgery in adult individuals was also modulated in children undergoing lifestyle intervention, suggesting they may constitute a core circulating lipid profile signature indicative of early development of obesity and improvement after clinical interventions regardless of individual age. MDPI 2023-07-27 /pmc/articles/PMC10421258/ /pubmed/37571279 http://dx.doi.org/10.3390/nu15153341 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Soria-Gondek, Andrea
Fernández-García, Pablo
González, Lorena
Reyes-Farias, Marjorie
Murillo, Marta
Valls, Aina
Real, Nativitat
Pellitero, Silvia
Tarascó, Jordi
Jenkins, Benjamin
Galán, María
Villarroya, Francesc
Koulman, Albert
Corrales, Patricia
Vidal-Puig, Antonio
Cereijo, Rubén
Sánchez-Infantes, David
Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study
title Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study
title_full Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study
title_fullStr Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study
title_full_unstemmed Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study
title_short Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study
title_sort lipidome profiling in childhood obesity compared to adults: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421258/
https://www.ncbi.nlm.nih.gov/pubmed/37571279
http://dx.doi.org/10.3390/nu15153341
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