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Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications
The combination of photothermal and magnetic functionalities in one biocompatible nanoformulation forms an attractive basis for developing multifunctional agents for biomedical theranostics. Here, we report the fabrication of silicon–iron (Si-Fe) composite nanoparticles (NPs) for theranostic applica...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421319/ https://www.ncbi.nlm.nih.gov/pubmed/37570573 http://dx.doi.org/10.3390/nano13152256 |
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author | Bubnov, Alexander A. Belov, Vladimir S. Kargina, Yulia V. Tikhonowski, Gleb V. Popov, Anton A. Kharin, Alexander Yu. Shestakov, Mikhail V. Perepukhov, Alexander M. Syuy, Alexander V. Volkov, Valentyn S. Khovaylo, Vladimir V. Klimentov, Sergey M. Kabashin, Andrei V. Timoshenko, Victor Yu. |
author_facet | Bubnov, Alexander A. Belov, Vladimir S. Kargina, Yulia V. Tikhonowski, Gleb V. Popov, Anton A. Kharin, Alexander Yu. Shestakov, Mikhail V. Perepukhov, Alexander M. Syuy, Alexander V. Volkov, Valentyn S. Khovaylo, Vladimir V. Klimentov, Sergey M. Kabashin, Andrei V. Timoshenko, Victor Yu. |
author_sort | Bubnov, Alexander A. |
collection | PubMed |
description | The combination of photothermal and magnetic functionalities in one biocompatible nanoformulation forms an attractive basis for developing multifunctional agents for biomedical theranostics. Here, we report the fabrication of silicon–iron (Si-Fe) composite nanoparticles (NPs) for theranostic applications by using a method of femtosecond laser ablation in acetone from a mixed target combining silicon and iron. The NPs were then transferred to water for subsequent biological use. From structural analyses, it was shown that the formed Si-Fe NPs have a spherical shape and sizes ranging from 5 to 150 nm, with the presence of two characteristic maxima around 20 nm and 90 nm in the size distribution. They are mostly composed of silicon with the presence of a significant iron silicide content and iron oxide inclusions. Our studies also show that the NPs exhibit magnetic properties due to the presence of iron ions in their composition, which makes the formation of contrast in magnetic resonance imaging (MRI) possible, as it is verified by magnetic resonance relaxometry at the proton resonance frequency. In addition, the Si-Fe NPs are characterized by strong optical absorption in the window of relative transparency of bio-tissue (650–950 nm). Benefiting from such absorption, the Si-Fe NPs provide strong photoheating in their aqueous suspensions under continuous wave laser excitation at 808 nm. The NP-induced photoheating is described by a photothermal conversion efficiency of 33–42%, which is approximately 3.0–3.3 times larger than that for pure laser-synthesized Si NPs, and it is explained by the presence of iron silicide in the NP composition. Combining the strong photothermal effect and MRI functionality, the synthesized Si-Fe NPs promise a major advancement of modalities for cancer theranostics, including MRI-guided photothermal therapy and surgery. |
format | Online Article Text |
id | pubmed-10421319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104213192023-08-12 Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications Bubnov, Alexander A. Belov, Vladimir S. Kargina, Yulia V. Tikhonowski, Gleb V. Popov, Anton A. Kharin, Alexander Yu. Shestakov, Mikhail V. Perepukhov, Alexander M. Syuy, Alexander V. Volkov, Valentyn S. Khovaylo, Vladimir V. Klimentov, Sergey M. Kabashin, Andrei V. Timoshenko, Victor Yu. Nanomaterials (Basel) Article The combination of photothermal and magnetic functionalities in one biocompatible nanoformulation forms an attractive basis for developing multifunctional agents for biomedical theranostics. Here, we report the fabrication of silicon–iron (Si-Fe) composite nanoparticles (NPs) for theranostic applications by using a method of femtosecond laser ablation in acetone from a mixed target combining silicon and iron. The NPs were then transferred to water for subsequent biological use. From structural analyses, it was shown that the formed Si-Fe NPs have a spherical shape and sizes ranging from 5 to 150 nm, with the presence of two characteristic maxima around 20 nm and 90 nm in the size distribution. They are mostly composed of silicon with the presence of a significant iron silicide content and iron oxide inclusions. Our studies also show that the NPs exhibit magnetic properties due to the presence of iron ions in their composition, which makes the formation of contrast in magnetic resonance imaging (MRI) possible, as it is verified by magnetic resonance relaxometry at the proton resonance frequency. In addition, the Si-Fe NPs are characterized by strong optical absorption in the window of relative transparency of bio-tissue (650–950 nm). Benefiting from such absorption, the Si-Fe NPs provide strong photoheating in their aqueous suspensions under continuous wave laser excitation at 808 nm. The NP-induced photoheating is described by a photothermal conversion efficiency of 33–42%, which is approximately 3.0–3.3 times larger than that for pure laser-synthesized Si NPs, and it is explained by the presence of iron silicide in the NP composition. Combining the strong photothermal effect and MRI functionality, the synthesized Si-Fe NPs promise a major advancement of modalities for cancer theranostics, including MRI-guided photothermal therapy and surgery. MDPI 2023-08-05 /pmc/articles/PMC10421319/ /pubmed/37570573 http://dx.doi.org/10.3390/nano13152256 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bubnov, Alexander A. Belov, Vladimir S. Kargina, Yulia V. Tikhonowski, Gleb V. Popov, Anton A. Kharin, Alexander Yu. Shestakov, Mikhail V. Perepukhov, Alexander M. Syuy, Alexander V. Volkov, Valentyn S. Khovaylo, Vladimir V. Klimentov, Sergey M. Kabashin, Andrei V. Timoshenko, Victor Yu. Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications |
title | Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications |
title_full | Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications |
title_fullStr | Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications |
title_full_unstemmed | Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications |
title_short | Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications |
title_sort | laser-ablative synthesis of silicon–iron composite nanoparticles for theranostic applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421319/ https://www.ncbi.nlm.nih.gov/pubmed/37570573 http://dx.doi.org/10.3390/nano13152256 |
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