Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome

Bile acids are acknowledged as signaling molecules involved in metabolic syndrome. The Takeda G protein-coupled receptor 5 (TGR5) functions as a significant bile acid receptor. The accumulated evidence suggests that TGR5 involves lipid homeostasis, glucose metabolism, and inflammation regulation. In...

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Autores principales: Gou, Xianmei, Qin, Lin, Wu, Di, Xie, Jian, Lu, Yanliu, Zhang, Qianru, He, Yuqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421342/
https://www.ncbi.nlm.nih.gov/pubmed/37570840
http://dx.doi.org/10.3390/molecules28155870
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author Gou, Xianmei
Qin, Lin
Wu, Di
Xie, Jian
Lu, Yanliu
Zhang, Qianru
He, Yuqi
author_facet Gou, Xianmei
Qin, Lin
Wu, Di
Xie, Jian
Lu, Yanliu
Zhang, Qianru
He, Yuqi
author_sort Gou, Xianmei
collection PubMed
description Bile acids are acknowledged as signaling molecules involved in metabolic syndrome. The Takeda G protein-coupled receptor 5 (TGR5) functions as a significant bile acid receptor. The accumulated evidence suggests that TGR5 involves lipid homeostasis, glucose metabolism, and inflammation regulation. In line with this, recent preclinical studies also demonstrate that TGR5 plays a significant role in the generation and progression of metabolic syndrome, encompassing type 2 diabetes mellitus, obesity, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). In this review, we discuss the role of TGR5 in metabolic syndrome, illustrating the underlying mechanisms and therapeutic targets.
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spelling pubmed-104213422023-08-12 Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome Gou, Xianmei Qin, Lin Wu, Di Xie, Jian Lu, Yanliu Zhang, Qianru He, Yuqi Molecules Review Bile acids are acknowledged as signaling molecules involved in metabolic syndrome. The Takeda G protein-coupled receptor 5 (TGR5) functions as a significant bile acid receptor. The accumulated evidence suggests that TGR5 involves lipid homeostasis, glucose metabolism, and inflammation regulation. In line with this, recent preclinical studies also demonstrate that TGR5 plays a significant role in the generation and progression of metabolic syndrome, encompassing type 2 diabetes mellitus, obesity, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). In this review, we discuss the role of TGR5 in metabolic syndrome, illustrating the underlying mechanisms and therapeutic targets. MDPI 2023-08-04 /pmc/articles/PMC10421342/ /pubmed/37570840 http://dx.doi.org/10.3390/molecules28155870 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gou, Xianmei
Qin, Lin
Wu, Di
Xie, Jian
Lu, Yanliu
Zhang, Qianru
He, Yuqi
Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome
title Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome
title_full Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome
title_fullStr Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome
title_full_unstemmed Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome
title_short Research Progress of Takeda G Protein-Coupled Receptor 5 in Metabolic Syndrome
title_sort research progress of takeda g protein-coupled receptor 5 in metabolic syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421342/
https://www.ncbi.nlm.nih.gov/pubmed/37570840
http://dx.doi.org/10.3390/molecules28155870
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