Cargando…
Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake
Obesity is a multifactorial disease that continues to increase in prevalence worldwide. Emerging evidence has shown that the development of obesity may be influenced by taxonomic shifts in gut microbiota in response to the consumption of dietary fats. Further, these alterations in gut microbiota hav...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421457/ https://www.ncbi.nlm.nih.gov/pubmed/37571301 http://dx.doi.org/10.3390/nu15153365 |
_version_ | 1785088985317507072 |
---|---|
author | Hamamah, Sevag Amin, Arman Al-Kassir, Abdul Latif Chuang, Judith Covasa, Mihai |
author_facet | Hamamah, Sevag Amin, Arman Al-Kassir, Abdul Latif Chuang, Judith Covasa, Mihai |
author_sort | Hamamah, Sevag |
collection | PubMed |
description | Obesity is a multifactorial disease that continues to increase in prevalence worldwide. Emerging evidence has shown that the development of obesity may be influenced by taxonomic shifts in gut microbiota in response to the consumption of dietary fats. Further, these alterations in gut microbiota have been shown to promote important changes in satiation signals including gut hormones (leptin, ghrelin, GLP-1, peptide YY and CCK) and orexigenic and anorexigenic neuropeptides (AgRP, NPY, POMC, CART) that influence hyperphagia and therefore obesity. In this review, we highlight mechanisms by which gut microbiota can influence these satiation signals both locally in the gastrointestinal tract and via microbiota-gut-brain communication. Then, we describe the effects of dietary interventions and associated changes in gut microbiota on satiety signals through microbiota-dependent mechanisms. Lastly, we present microbiota optimizing therapies including prebiotics, probiotics, synbiotics and weight loss surgery that can help restore beneficial gut microbiota by enhancing satiety signals to reduce hyperphagia and subsequent obesity. Overall, a better understanding of the mechanisms by which dietary fats induce taxonomical shifts in gut microbiota and their impact on satiation signaling pathways will help develop more targeted therapeutic interventions in delaying the onset of obesity and in furthering its treatment. |
format | Online Article Text |
id | pubmed-10421457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104214572023-08-12 Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake Hamamah, Sevag Amin, Arman Al-Kassir, Abdul Latif Chuang, Judith Covasa, Mihai Nutrients Review Obesity is a multifactorial disease that continues to increase in prevalence worldwide. Emerging evidence has shown that the development of obesity may be influenced by taxonomic shifts in gut microbiota in response to the consumption of dietary fats. Further, these alterations in gut microbiota have been shown to promote important changes in satiation signals including gut hormones (leptin, ghrelin, GLP-1, peptide YY and CCK) and orexigenic and anorexigenic neuropeptides (AgRP, NPY, POMC, CART) that influence hyperphagia and therefore obesity. In this review, we highlight mechanisms by which gut microbiota can influence these satiation signals both locally in the gastrointestinal tract and via microbiota-gut-brain communication. Then, we describe the effects of dietary interventions and associated changes in gut microbiota on satiety signals through microbiota-dependent mechanisms. Lastly, we present microbiota optimizing therapies including prebiotics, probiotics, synbiotics and weight loss surgery that can help restore beneficial gut microbiota by enhancing satiety signals to reduce hyperphagia and subsequent obesity. Overall, a better understanding of the mechanisms by which dietary fats induce taxonomical shifts in gut microbiota and their impact on satiation signaling pathways will help develop more targeted therapeutic interventions in delaying the onset of obesity and in furthering its treatment. MDPI 2023-07-28 /pmc/articles/PMC10421457/ /pubmed/37571301 http://dx.doi.org/10.3390/nu15153365 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hamamah, Sevag Amin, Arman Al-Kassir, Abdul Latif Chuang, Judith Covasa, Mihai Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake |
title | Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake |
title_full | Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake |
title_fullStr | Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake |
title_full_unstemmed | Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake |
title_short | Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake |
title_sort | dietary fat modulation of gut microbiota and impact on regulatory pathways controlling food intake |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421457/ https://www.ncbi.nlm.nih.gov/pubmed/37571301 http://dx.doi.org/10.3390/nu15153365 |
work_keys_str_mv | AT hamamahsevag dietaryfatmodulationofgutmicrobiotaandimpactonregulatorypathwayscontrollingfoodintake AT aminarman dietaryfatmodulationofgutmicrobiotaandimpactonregulatorypathwayscontrollingfoodintake AT alkassirabdullatif dietaryfatmodulationofgutmicrobiotaandimpactonregulatorypathwayscontrollingfoodintake AT chuangjudith dietaryfatmodulationofgutmicrobiotaandimpactonregulatorypathwayscontrollingfoodintake AT covasamihai dietaryfatmodulationofgutmicrobiotaandimpactonregulatorypathwayscontrollingfoodintake |