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Bioactive Metabolites from Terrestrial and Marine Actinomycetes

Actinomycetes inhabit both terrestrial and marine ecosystems and are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, and antiviral activities. In this review, we delve into the life cycle, ecolo...

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Detalles Bibliográficos
Autores principales: Ngamcharungchit, Chananan, Chaimusik, Nutsuda, Panbangred, Watanalai, Euanorasetr, Jirayut, Intra, Bungonsiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421486/
https://www.ncbi.nlm.nih.gov/pubmed/37570885
http://dx.doi.org/10.3390/molecules28155915
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author Ngamcharungchit, Chananan
Chaimusik, Nutsuda
Panbangred, Watanalai
Euanorasetr, Jirayut
Intra, Bungonsiri
author_facet Ngamcharungchit, Chananan
Chaimusik, Nutsuda
Panbangred, Watanalai
Euanorasetr, Jirayut
Intra, Bungonsiri
author_sort Ngamcharungchit, Chananan
collection PubMed
description Actinomycetes inhabit both terrestrial and marine ecosystems and are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, and antiviral activities. In this review, we delve into the life cycle, ecology, taxonomy, and classification of actinomycetes, as well as their varied bioactive metabolites recently discovered between 2015 and 2023. Additionally, we explore promising strategies to unveil and investigate new bioactive metabolites, encompassing genome mining, activation of silent genes through signal molecules, and co-cultivation approaches. By presenting this comprehensive and up-to-date review, we hope to offer a potential solution to uncover novel bioactive compounds with essential activities.
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spelling pubmed-104214862023-08-12 Bioactive Metabolites from Terrestrial and Marine Actinomycetes Ngamcharungchit, Chananan Chaimusik, Nutsuda Panbangred, Watanalai Euanorasetr, Jirayut Intra, Bungonsiri Molecules Review Actinomycetes inhabit both terrestrial and marine ecosystems and are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, and antiviral activities. In this review, we delve into the life cycle, ecology, taxonomy, and classification of actinomycetes, as well as their varied bioactive metabolites recently discovered between 2015 and 2023. Additionally, we explore promising strategies to unveil and investigate new bioactive metabolites, encompassing genome mining, activation of silent genes through signal molecules, and co-cultivation approaches. By presenting this comprehensive and up-to-date review, we hope to offer a potential solution to uncover novel bioactive compounds with essential activities. MDPI 2023-08-06 /pmc/articles/PMC10421486/ /pubmed/37570885 http://dx.doi.org/10.3390/molecules28155915 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ngamcharungchit, Chananan
Chaimusik, Nutsuda
Panbangred, Watanalai
Euanorasetr, Jirayut
Intra, Bungonsiri
Bioactive Metabolites from Terrestrial and Marine Actinomycetes
title Bioactive Metabolites from Terrestrial and Marine Actinomycetes
title_full Bioactive Metabolites from Terrestrial and Marine Actinomycetes
title_fullStr Bioactive Metabolites from Terrestrial and Marine Actinomycetes
title_full_unstemmed Bioactive Metabolites from Terrestrial and Marine Actinomycetes
title_short Bioactive Metabolites from Terrestrial and Marine Actinomycetes
title_sort bioactive metabolites from terrestrial and marine actinomycetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421486/
https://www.ncbi.nlm.nih.gov/pubmed/37570885
http://dx.doi.org/10.3390/molecules28155915
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