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Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice

Healthcare is an emerging industry with significant market potential in the 21st century. Therefore, this study aimed to evaluate the benefits of tube feeding Huáng qí and its complexes for 8 weeks on 3-month-old senescence-accelerated mouse prone-8 (SAMP8) mice, 48 in total, randomly divided into 3...

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Autores principales: Chou, Ming-Yu, Wong, Yue-Ching, Wang, Shih-Yi, Chi, Ching-Hsin, Wang, Teng-Hsu, Huang, Mao-Jung, Huang, Ping-Hsiu, Li, Po-Hsien, Wang, Ming-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421658/
https://www.ncbi.nlm.nih.gov/pubmed/37575325
http://dx.doi.org/10.3389/fnut.2023.1235780
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author Chou, Ming-Yu
Wong, Yue-Ching
Wang, Shih-Yi
Chi, Ching-Hsin
Wang, Teng-Hsu
Huang, Mao-Jung
Huang, Ping-Hsiu
Li, Po-Hsien
Wang, Ming-Fu
author_facet Chou, Ming-Yu
Wong, Yue-Ching
Wang, Shih-Yi
Chi, Ching-Hsin
Wang, Teng-Hsu
Huang, Mao-Jung
Huang, Ping-Hsiu
Li, Po-Hsien
Wang, Ming-Fu
author_sort Chou, Ming-Yu
collection PubMed
description Healthcare is an emerging industry with significant market potential in the 21st century. Therefore, this study aimed to evaluate the benefits of tube feeding Huáng qí and its complexes for 8 weeks on 3-month-old senescence-accelerated mouse prone-8 (SAMP8) mice, 48 in total, randomly divided into 3 groups including control, Huáng qí extract [820 mg/kg Body weight (BW)/day], and Huáng qí complexes (6.2 mL /kg BW/day), where each group consisted of males (n = 8) and females (n = 8). Behavioral tests (locomotion test and aging score assessment on week 6, the single-trial passive avoidance test on week 7, and the active shuttle avoidance test on week 8) were conducted to evaluate the ability of the mice to learn and remember. In addition, after sacrificing the animals, the blood and organs were measured for antioxidant and aging bioactivities, including malondialdehyde (MDA) content and superoxide dismutase (SOD) activity and catalase activities (CAT), and the effects on promoting aging in SAMP8 mice were investigated. The findings showed that Huáng qí enhanced locomotor performance and had anti-aging effects, with positive effects on health, learning, and memory in SAMP-8 mice (p < 0.05), whether applied as a single agent (820 mg/kg BW/day) or as a complex (6.2 mL/kg BW/day) (p < 0.05). Based on existing strengths, a more compelling platform for clinical validation of human clinical evidence will be established to enhance the development and value-added of astragalus-related products while meeting the diversified needs of the functional food market.
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spelling pubmed-104216582023-08-12 Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice Chou, Ming-Yu Wong, Yue-Ching Wang, Shih-Yi Chi, Ching-Hsin Wang, Teng-Hsu Huang, Mao-Jung Huang, Ping-Hsiu Li, Po-Hsien Wang, Ming-Fu Front Nutr Nutrition Healthcare is an emerging industry with significant market potential in the 21st century. Therefore, this study aimed to evaluate the benefits of tube feeding Huáng qí and its complexes for 8 weeks on 3-month-old senescence-accelerated mouse prone-8 (SAMP8) mice, 48 in total, randomly divided into 3 groups including control, Huáng qí extract [820 mg/kg Body weight (BW)/day], and Huáng qí complexes (6.2 mL /kg BW/day), where each group consisted of males (n = 8) and females (n = 8). Behavioral tests (locomotion test and aging score assessment on week 6, the single-trial passive avoidance test on week 7, and the active shuttle avoidance test on week 8) were conducted to evaluate the ability of the mice to learn and remember. In addition, after sacrificing the animals, the blood and organs were measured for antioxidant and aging bioactivities, including malondialdehyde (MDA) content and superoxide dismutase (SOD) activity and catalase activities (CAT), and the effects on promoting aging in SAMP8 mice were investigated. The findings showed that Huáng qí enhanced locomotor performance and had anti-aging effects, with positive effects on health, learning, and memory in SAMP-8 mice (p < 0.05), whether applied as a single agent (820 mg/kg BW/day) or as a complex (6.2 mL/kg BW/day) (p < 0.05). Based on existing strengths, a more compelling platform for clinical validation of human clinical evidence will be established to enhance the development and value-added of astragalus-related products while meeting the diversified needs of the functional food market. Frontiers Media S.A. 2023-07-28 /pmc/articles/PMC10421658/ /pubmed/37575325 http://dx.doi.org/10.3389/fnut.2023.1235780 Text en Copyright © 2023 Chou, Wong, Wang, Chi, Wang, Huang, Huang, Li and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Chou, Ming-Yu
Wong, Yue-Ching
Wang, Shih-Yi
Chi, Ching-Hsin
Wang, Teng-Hsu
Huang, Mao-Jung
Huang, Ping-Hsiu
Li, Po-Hsien
Wang, Ming-Fu
Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice
title Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice
title_full Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice
title_fullStr Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice
title_full_unstemmed Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice
title_short Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice
title_sort potential antidepressant effects of a dietary supplement from huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421658/
https://www.ncbi.nlm.nih.gov/pubmed/37575325
http://dx.doi.org/10.3389/fnut.2023.1235780
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