Activation of invasion by oncogenic reprogramming of cholesterol metabolism via increased NPC1 expression and macropinocytosis

Cancer cells are dependent on cholesterol, and they possess strictly controlled cholesterol homeostasis mechanisms. These allow them to smoothly switch between cholesterol synthesis and uptake to fulfill their needs and to adapt environmental changes. Here we describe a mechanism of how cancer cells...

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Detalles Bibliográficos
Autores principales: Skorda, Aikaterini, Lauridsen, Anna Røssberg, Wu, Chengnan, Huang, Jinrong, Mrackova, Monika, Winther, Nuggi Ingholt, Jank, Vanessa, Sztupinszki, Zsofia, Strauss, Robert, Bilgin, Mesut, Maeda, Kenji, Liu, Bin, Luo, Yonglun, Jäättelä, Marja, Kallunki, Tuula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421736/
https://www.ncbi.nlm.nih.gov/pubmed/37420029
http://dx.doi.org/10.1038/s41388-023-02771-x

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