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Influence of the toxicological status on the diagnosis of fatal drowning
Drowning is the leading cause of death by accident of everyday life in people under 25 years of age. Xenobiotics are frequently involved in drowning cases but their influence on the diagnosis of fatal drowning has not been studied so far. This preliminary study aimed to assess the influence of an al...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421782/ https://www.ncbi.nlm.nih.gov/pubmed/37433906 http://dx.doi.org/10.1007/s00414-023-03057-3 |
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author | Poulain, Clément Mathieu, Olivier Gouetta, Valérie Baccino, Éric Peyron, Pierre-Antoine |
author_facet | Poulain, Clément Mathieu, Olivier Gouetta, Valérie Baccino, Éric Peyron, Pierre-Antoine |
author_sort | Poulain, Clément |
collection | PubMed |
description | Drowning is the leading cause of death by accident of everyday life in people under 25 years of age. Xenobiotics are frequently involved in drowning cases but their influence on the diagnosis of fatal drowning has not been studied so far. This preliminary study aimed to assess the influence of an alcohol and/or a drug intoxication on the autopsy signs of drowning, and on the results of diatom analyses in drowning deaths. Twenty-eight autopsy cases of drowning including 19 freshwater drownings, 6 seawater drownings, and 3 brackish water drownings were prospectively included. Toxicological and diatom tests were performed in each case. The influence of alcohol and other xenobiotics on drowning signs and diatom analyses was assessed separately then in combination through a global toxicological participation score (GTPS). Diatom analyses showed positive results in lung tissue in every case. No significant association was found between the degree of intoxication and the diatom concentration in the organs, even after considering freshwater drowning cases only. The vast majority of the traditional autopsy signs of drowning were not significantly affected by the individual toxicological status either, with the exception of lung weight which tended to raise in case of intoxication, probably due to the pulmonary edema and congestion increase. Further research on larger autopsy samples is needed to confirm the results of this exploratory study. |
format | Online Article Text |
id | pubmed-10421782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-104217822023-08-13 Influence of the toxicological status on the diagnosis of fatal drowning Poulain, Clément Mathieu, Olivier Gouetta, Valérie Baccino, Éric Peyron, Pierre-Antoine Int J Legal Med Original Article Drowning is the leading cause of death by accident of everyday life in people under 25 years of age. Xenobiotics are frequently involved in drowning cases but their influence on the diagnosis of fatal drowning has not been studied so far. This preliminary study aimed to assess the influence of an alcohol and/or a drug intoxication on the autopsy signs of drowning, and on the results of diatom analyses in drowning deaths. Twenty-eight autopsy cases of drowning including 19 freshwater drownings, 6 seawater drownings, and 3 brackish water drownings were prospectively included. Toxicological and diatom tests were performed in each case. The influence of alcohol and other xenobiotics on drowning signs and diatom analyses was assessed separately then in combination through a global toxicological participation score (GTPS). Diatom analyses showed positive results in lung tissue in every case. No significant association was found between the degree of intoxication and the diatom concentration in the organs, even after considering freshwater drowning cases only. The vast majority of the traditional autopsy signs of drowning were not significantly affected by the individual toxicological status either, with the exception of lung weight which tended to raise in case of intoxication, probably due to the pulmonary edema and congestion increase. Further research on larger autopsy samples is needed to confirm the results of this exploratory study. Springer Berlin Heidelberg 2023-07-11 2023 /pmc/articles/PMC10421782/ /pubmed/37433906 http://dx.doi.org/10.1007/s00414-023-03057-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Poulain, Clément Mathieu, Olivier Gouetta, Valérie Baccino, Éric Peyron, Pierre-Antoine Influence of the toxicological status on the diagnosis of fatal drowning |
title | Influence of the toxicological status on the diagnosis of fatal drowning |
title_full | Influence of the toxicological status on the diagnosis of fatal drowning |
title_fullStr | Influence of the toxicological status on the diagnosis of fatal drowning |
title_full_unstemmed | Influence of the toxicological status on the diagnosis of fatal drowning |
title_short | Influence of the toxicological status on the diagnosis of fatal drowning |
title_sort | influence of the toxicological status on the diagnosis of fatal drowning |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421782/ https://www.ncbi.nlm.nih.gov/pubmed/37433906 http://dx.doi.org/10.1007/s00414-023-03057-3 |
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