Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer’s disease pathology

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Patients with Alzheimer’s disease (AD) exhibit non-rapid eye movement (NREM) sleep disturbances in addition to memory deficits. Disruption of NREM slow waves occurs early in the disease progression and is recapitulated in transgenic mouse models of beta-amyloidosis. However, the mechanisms underlyin...

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Detalles Bibliográficos
Autores principales: Lee, Yee Fun, Russ, Alyssa N., Zhao, Qiuchen, Perle, Stephen J., Maci, Megi, Miller, Morgan R., Hou, Steven S., Algamal, Moustafa, Zhao, Zhuoyang, Li, Hanyan, Gelwan, Noah, Liu, Zhe, Gomperts, Stephen N., Araque, Alfonso, Galea, Elena, Bacskai, Brian J., Kastanenka, Ksenia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421876/
https://www.ncbi.nlm.nih.gov/pubmed/37567942
http://dx.doi.org/10.1038/s41598-023-40402-3
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