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Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy

BACKGROUND: The effectiveness of conservative treatment of endometrial carcinoma (EC) with oral progesterone therapy, such as medroxyprogesterone acetate (MPA), can be blunted due to primary or acquired resistance, but the underlying mechanisms remain incompletely defined. METHODS: Genome-wide CRISP...

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Detalles Bibliográficos
Autores principales:	Zhang, Zijing, Zhang, Meng, Zhou, Jingyi, Wang, Donglai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421920/ https://www.ncbi.nlm.nih.gov/pubmed/37402867 http://dx.doi.org/10.1038/s41416-023-02347-2

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