Cargando…

A promising small molecule binding pocket in class B GPCRs: expanding potential for drug development

Detalles Bibliográficos
Autores principales:	Xiao, Huan, Sun, Qian, Sun, Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Research Highlight
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421945/ https://www.ncbi.nlm.nih.gov/pubmed/37567868 http://dx.doi.org/10.1038/s41392-023-01598-y

Ejemplares similares

The Impact of the Secondary Binding Pocket on the Pharmacology of Class A GPCRs
por: Egyed, Attila, et al.
Publicado: (2022)

Allosteric coupling from G protein to the agonist binding pocket in GPCRs
por: DeVree, Brian T., et al.
Publicado: (2016)

The expanding world of stem cell modeling of Huntington's disease: creating tools with a promising future
por: Ward, Jacqueline M, et al.
Publicado: (2012)

Identification of Potential Small Molecule Binding Pockets on Rho Family GTPases
por: Ortiz-Sanchez, Juan Manuel, et al.
Publicado: (2012)

Selenium-containing small molecules
por: Guo, Huijuan
Publicado: (2022)

Cyro-EM structure of human mGlus: leading therapeutic potential to neurological diseases
por: Xiao, Huan, et al.
Publicado: (2021)

Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery
por: Kolluru, Srikanth, et al.
Publicado: (2019)

A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues
por: Min, Long, et al.
Publicado: (2022)

Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs
por: Huber, Max E., et al.
Publicado: (2022)

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs
por: Hollingsworth, Scott A., et al.
Publicado: (2019)

Peripheral and systemic antigens elicit an expandable pool of resident memory CD8(+) T cells in the bone marrow
por: Pascutti, Maria Fernanda, et al.
Publicado: (2019)

In search for novel strategies towards neuroprotection and neuroregeneration: is PPARα a promising therapeutic target?
por: Moreno, Sandra, et al.
Publicado: (2015)

A Comprehensive Survey of Small-Molecule Binding Pockets in Proteins
por: Gao, Mu, et al.
Publicado: (2013)

Mending a broken heart with novel cardiogenic small molecules
por: Powers, Nevan, et al.
Publicado: (2022)

The pockets guide to HLA class I molecules
por: Nguyen, Andrea T., et al.
Publicado: (2021)

Common activation mechanism of class A GPCRs
por: Zhou, Qingtong, et al.
Publicado: (2019)

Allosteric Modulation of GPCRs of Class A by Cholesterol
por: Jakubík, Jan, et al.
Publicado: (2021)

Activation and Speciation Mechanisms in Class A GPCRs
por: Wingert, Bentley, et al.
Publicado: (2022)

High-throughput base editing: a promising technology for precision medicine and drug discovery
por: Sachinidis, Agapios
Publicado: (2021)

Identification of a Sialosides binding pocket in early-lineage SARS-CoV-2 via an optimized STD NMR method: a novel explanation for coronavirus virulence and zoonosis
por: Chen, Geng, et al.
Publicado: (2022)

Soluble pattern recognition molecules: Guardians and regulators of homeostasis at airway mucosal surfaces
por: Smole, Ursula, et al.
Publicado: (2020)

An Overview on GPCRs and Drug Discovery: Structure-Based Drug Design and Structural Biology on GPCRs
por: Lundstrom, Kenneth
Publicado: (2009)

The expanding vulnerabilities of being UTXless
por: Jiang, Hai
Publicado: (2019)

Kidney injury molecule-1: a novel entry factor for SARS-CoV-2
por: Wan, Cheng, et al.
Publicado: (2021)

Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation
por: Rana, Sandeep, et al.
Publicado: (2021)

Structures of BRAF–MEK1–14-3-3 sheds light on drug discovery
por: Sun, Qiu, et al.
Publicado: (2019)

Binding kinetics of ligands acting at GPCRs
por: Sykes, David A., et al.
Publicado: (2019)

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation
por: Dingler, Felix A., et al.
Publicado: (2014)

Multiple LDLR class A repeats on very‐low‐density lipoprotein receptor promote the cross‐species transmission of Semliki Forest virus
por: Hu, Ruolan, et al.
Publicado: (2023)

Promising inhibitors targeting M(pro): an ideal strategy for anti-SARS-CoV-2 drug discovery
por: Chen, Yi, et al.
Publicado: (2020)

The role of Cysteine 6.47 in class A GPCRs
por: Olivella, Mireia, et al.
Publicado: (2013)

Cholesterol in Class C GPCRs: Role, Relevance, and Localization
por: Isu, Ugochi H., et al.
Publicado: (2023)

EDS1 modules as two-tiered receptor complexes for TIR-catalyzed signaling molecules to activate plant immunity
por: Li, Jia, et al.
Publicado: (2022)

Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
por: Ferruz, Noelia, et al.
Publicado: (2018)

Small and mighty – microRNAs pulling the strings
por: Kattner, Aila Akosua
Publicado: (2022)

Drug-induced diabetes type 2: In silico study involving class B GPCRs
por: Latek, Dorota, et al.
Publicado: (2019)

Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?
por: Cosín-Roger, Jesús, et al.
Publicado: (2020)

Promising biotechnological applications of antibiofilm exopolysaccharides
por: Bernal, Patricia, et al.
Publicado: (2012)

Highlight—Small Genomes for the Swift: Of Flight and Intron Size
por: Venton, Danielle
Publicado: (2012)

Targeting H3K36 methyltransferases NSDs: a promising strategy for tumor targeted therapy
por: Peng, Xuerun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vgm5ktgafodha5beidreho2okm