Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial

BACKGROUND: Pre-clinical models demonstrate that platelet activation is involved in the spread of malignancy. Ongoing clinical trials are assessing whether aspirin, which inhibits platelet activation, can prevent or delay metastases. METHODS: Urinary 11-dehydro-thromboxane B(2) (U-TXM), a biomarker...

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Detalles Bibliográficos
Autores principales: Joharatnam-Hogan, Nalinie, Hatem, Duaa, Cafferty, Fay H., Petrucci, Giovanna, Cameron, David A., Ring, Alistair, Kynaston, Howard G., Gilbert, Duncan C., Wilson, Richard H., Hubner, Richard A., Swinson, Daniel E. B., Cleary, Siobhan, Robbins, Alex, MacKenzie, Mairead, Scott-Brown, Martin W. G., Sothi, Sharmila, Dawson, Lesley K., Capaldi, Lisa M., Churn, Mark, Cunningham, David, Khoo, Vincent, Armstrong, Anne C., Ainsworth, Nicola L., Horan, Gail, Wheatley, Duncan A., Mullen, Russell, Lofts, Fiona J., Walther, Axel, Herbertson, Rebecca A., Eaton, John D., O’Callaghan, Ann, Eichholz, Andrew, Kagzi, Mohammed M., Patterson, Daniel M., Narahari, Krishna, Bradbury, Jennifer, Stokes, Zuzana, Rizvi, Azhar J., Walker, Georgina A., Kunene, Victoria L., Srihari, Narayanan, Gentry-Maharaj, Aleksandra, Meade, Angela, Patrono, Carlo, Rocca, Bianca, Langley, Ruth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421951/
https://www.ncbi.nlm.nih.gov/pubmed/37420000
http://dx.doi.org/10.1038/s41416-023-02310-1

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