Cargando…

Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes

OBJECTIVES: Better disease management can be achieved with earlier detection through robust, sensitive, and easily accessible biomarkers. The aim of the current study was to identify novel epigenetic biomarkers determining the risk of type 2 diabetes (T2D). METHODS: Livers of 10-week-old female New...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ouni, Meriem, Eichelmann, Fabian, Jähnert, Markus, Krause, Christin, Saussenthaler, Sophie, Ott, Christiane, Gottmann, Pascal, Speckmann, Thilo, Huypens, Peter, Wolter, Stefan, Mann, Oliver, De Angelis, Martin Hrabé, Beckers, Johannes, Kirchner, Henriette, Schulze, Matthias B., Schürmann, Annette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422014/ https://www.ncbi.nlm.nih.gov/pubmed/37429525 http://dx.doi.org/10.1016/j.molmet.2023.101774

Ejemplares similares

Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes
por: Ouni, Meriem, et al.
Publicado: (2020)

Identification of MicroRNAs Associated with Prediabetic Status in Obese Women
por: Kovac, Leona, et al.
Publicado: (2023)

Polymorphisms in miRNA binding sites involved in metabolic diseases in mice and humans
por: Gottmann, Pascal, et al.
Publicado: (2020)

Enriched Alternative Splicing in Islets of Diabetes-Susceptible Mice
por: Wilhelmi, Ilka, et al.
Publicado: (2021)

A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes
por: Gottmann, Pascal, et al.
Publicado: (2018)

Epigenetic contribution to obesity
por: Ouni, Meriem, et al.
Publicado: (2020)

Identification of Novel Genes Involved in Hyperglycemia in Mice
por: Jonas, Wenke, et al.
Publicado: (2022)

Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types
por: Neves, João V., et al.
Publicado: (2017)

Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice
por: Gottmann, Pascal, et al.
Publicado: (2022)

Alterations of Lipid Profile in Livers with Impaired Lipophagy
por: Jonas, Wenke, et al.
Publicado: (2022)

Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice
por: Kammel, Anne, et al.
Publicado: (2016)

Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis
por: Krause, Christin, et al.
Publicado: (2018)

HAMP Domain Conformers That Propagate Opposite Signals in Bacterial Chemoreceptors
por: Airola, Michael V., et al.
Publicado: (2013)

Reply to the letter to the editor by J. Hissbach, S. Zimmermann & W. Hampe
por: Kesternich, Iris, et al.
Publicado: (2017)

Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma
por: Kudo, Yuzan, et al.
Publicado: (2019)

Sox2 function as a negative regulator to control HAMP expression
por: Song, Bin, et al.
Publicado: (2015)

Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes
por: Krause, Christin, et al.
Publicado: (2020)

Juvenile hemochromatosis: HAMP mutation and severe iron overload treated with phlebotomies and deferasirox
por: Lescano, Manuel A, et al.
Publicado: (2017)

Conformational sampling of CpxA: Connecting HAMP motions to the histidine kinase function
por: Duclert-Savatier, Nathalie, et al.
Publicado: (2018)

HAMP as a Prognostic Biomarker for Colorectal Cancer Based on Tumor Microenvironment Analysis
por: Wei, Fang-Ze, et al.
Publicado: (2022)

Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition
por: Snoeck, Simon, et al.
Publicado: (2022)

Distinct Adipogenic and Fibrogenic Differentiation Capacities of Mesenchymal Stromal Cells from Pancreas and White Adipose Tissue
por: Aga, Heja, et al.
Publicado: (2022)

HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue
por: Hauffe, Robert, et al.
Publicado: (2021)

Comparison of Fatty Acid and Gene Profiles in Skeletal Muscle in Normal and Obese C57BL/6J Mice before and after Blunt Muscle Injury
por: Werner, Jens-Uwe, et al.
Publicado: (2018)

Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells
por: Gässler, Anneke, et al.
Publicado: (2020)

Molecular modeling of the HAMP domain of sensory rhodopsin II transducer from Natronomonas pharaonis
por: Nishikata, Koro, et al.
Publicado: (2010)

Cardiac Hamp mRNA Is Predominantly Expressed in the Right Atrium and Does Not Respond to Iron
por: Bigorra Mir, Maria, et al.
Publicado: (2023)

HAMP Domain Rotation and Tilting Movements Associated with Signal Transduction in the PhoQ Sensor Kinase
por: Matamouros, Susana, et al.
Publicado: (2015)

The complete chloroplast genome of Rhodobryum laxelimbatum (Hampe ex Ochi) Z. Iwatsuki and T. J. Koponen
por: Li, Shuangling, et al.
Publicado: (2021)

Dynamic changes of muscle insulin sensitivity after metabolic surgery
por: Gancheva, Sofiya, et al.
Publicado: (2019)

Author Correction: Dynamic changes of muscle insulin sensitivity after metabolic surgery
por: Gancheva, Sofiya, et al.
Publicado: (2022)

A vast genomic deletion in the C56BL/6 genome affects different genes within the Ifi200 cluster on chromosome 1 and mediates obesity and insulin resistance
por: Vogel, Heike, et al.
Publicado: (2017)

Fatty Acid Induced Hypermethylation in the Slc2a4 Gene in Visceral Adipose Tissue Is Associated to Insulin-Resistance and Obesity
por: Britsemmer, Jan H., et al.
Publicado: (2023)

Genetic study of the hepcidin gene (HAMP) promoter and functional analysis of the c.-582A > G variant
por: Parajes, Silvia, et al.
Publicado: (2010)

The HAMP Signal Relay Domain Adopts Multiple Conformational States through Collective Piston and Tilt Motions
por: Zhu, Lizhe, et al.
Publicado: (2013)

Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease
por: Huang, Ying-Hsien, et al.
Publicado: (2017)

HAMP as a Potential Diagnostic, PD-(L)1 Immunotherapy Sensitivity and Prognostic Biomarker in Hepatocellular Carcinoma
por: Chen, Guoming, et al.
Publicado: (2023)

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition
por: Shih, Alexis Z.L., et al.
Publicado: (2022)

Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin
por: Stirm, Laura, et al.
Publicado: (2018)

Author Correction: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin
por: Stirm, Laura, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_php5sfp9p17nkt80r8ocvk6afm