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Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics

Hydrogels have a three-dimensional network structure and high-water content, are similar in structure to the extracellular matrix, and are often used as wound dressings. Natural polymers have excellent biocompatibility and biodegradability and are commonly utilized to prepare hydrogels. Natural-poly...

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Detalles Bibliográficos
Autores principales: Zhao, Yue, Wang, Xiaoyu, Qi, Ruilian, Yuan, Huanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422483/
https://www.ncbi.nlm.nih.gov/pubmed/37571202
http://dx.doi.org/10.3390/polym15153305
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author Zhao, Yue
Wang, Xiaoyu
Qi, Ruilian
Yuan, Huanxiang
author_facet Zhao, Yue
Wang, Xiaoyu
Qi, Ruilian
Yuan, Huanxiang
author_sort Zhao, Yue
collection PubMed
description Hydrogels have a three-dimensional network structure and high-water content, are similar in structure to the extracellular matrix, and are often used as wound dressings. Natural polymers have excellent biocompatibility and biodegradability and are commonly utilized to prepare hydrogels. Natural-polymer-based hydrogels can have excellent antibacterial and bioactive properties by loading antibacterial agents or being combined with therapeutics such as phototherapy, which has great advantages in the field of treatment of microbial infections. In the published reviews of hydrogels used in the treatment of infectious wounds, the common classification criteria of hydrogels include function, source of antibacterial properties, type of antibacterial agent, etc. However, there are few reviews on the classification of hydrogels based on raw materials, and the description of natural-polymer-based hydrogels is not comprehensive and detailed. In this paper, based on the principle of material classification, the characteristics of seven types of natural polymers that can be used to prepare hydrogels are discussed, respectively, and the application of natural-polymer-based hydrogels in the treatment of infectious wounds is described in detail. Finally, the research status, limitations, and prospects of natural-polymer-based hydrogels are briefly discussed.
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spelling pubmed-104224832023-08-13 Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics Zhao, Yue Wang, Xiaoyu Qi, Ruilian Yuan, Huanxiang Polymers (Basel) Review Hydrogels have a three-dimensional network structure and high-water content, are similar in structure to the extracellular matrix, and are often used as wound dressings. Natural polymers have excellent biocompatibility and biodegradability and are commonly utilized to prepare hydrogels. Natural-polymer-based hydrogels can have excellent antibacterial and bioactive properties by loading antibacterial agents or being combined with therapeutics such as phototherapy, which has great advantages in the field of treatment of microbial infections. In the published reviews of hydrogels used in the treatment of infectious wounds, the common classification criteria of hydrogels include function, source of antibacterial properties, type of antibacterial agent, etc. However, there are few reviews on the classification of hydrogels based on raw materials, and the description of natural-polymer-based hydrogels is not comprehensive and detailed. In this paper, based on the principle of material classification, the characteristics of seven types of natural polymers that can be used to prepare hydrogels are discussed, respectively, and the application of natural-polymer-based hydrogels in the treatment of infectious wounds is described in detail. Finally, the research status, limitations, and prospects of natural-polymer-based hydrogels are briefly discussed. MDPI 2023-08-04 /pmc/articles/PMC10422483/ /pubmed/37571202 http://dx.doi.org/10.3390/polym15153305 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Yue
Wang, Xiaoyu
Qi, Ruilian
Yuan, Huanxiang
Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics
title Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics
title_full Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics
title_fullStr Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics
title_full_unstemmed Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics
title_short Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics
title_sort recent advances of natural-polymer-based hydrogels for wound antibacterial therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422483/
https://www.ncbi.nlm.nih.gov/pubmed/37571202
http://dx.doi.org/10.3390/polym15153305
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