Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression

Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineages, the trophectoderm (TE), the epiblast (EPI) and the primitive endoderm (PrE). Although key signaling pathways and transcription factors that control these early embryonic deci...

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Detalles Bibliográficos
Autores principales: Murphy, Dylan, Salataj, Eralda, Di Giammartino, Dafne Campigli, Rodriguez-Hernaez, Javier, Kloetgen, Andreas, Garg, Vidur, Char, Erin, Uyehara, Christopher M., Ee, Ly-sha, Lee, UkJin, Stadtfeld, Matthias, Hadjantonakis, Anna-Katerina, Tsirigos, Aristotelis, Polyzos, Alexander, Apostolou, Effie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422694/
https://www.ncbi.nlm.nih.gov/pubmed/37577543
http://dx.doi.org/10.1101/2023.07.19.549714

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