Cargando…

Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed

INTRODUCTION: The spleen is a responsible significant part of the immune system; after Splenectomy following trauma, the immune system changes; splenic autotransplantation can preserve the immune system after trauma and Splenectomy. BACKGROUND: Patients can be protected from immune dysfunction by au...

Descripción completa

Detalles Bibliográficos
Autores principales: Saad, Hassan A., Elsayed, Rasha S, Riad, Mohamed, El-Taher, Ahmed K., Eraky, Mohamed E, Abdelmonem, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422790/
https://www.ncbi.nlm.nih.gov/pubmed/37568135
http://dx.doi.org/10.1186/s12893-023-02126-z
_version_ 1785089299794886656
author Saad, Hassan A.
Elsayed, Rasha S
Riad, Mohamed
El-Taher, Ahmed K.
Eraky, Mohamed E
Abdelmonem, Ashraf
author_facet Saad, Hassan A.
Elsayed, Rasha S
Riad, Mohamed
El-Taher, Ahmed K.
Eraky, Mohamed E
Abdelmonem, Ashraf
author_sort Saad, Hassan A.
collection PubMed
description INTRODUCTION: The spleen is a responsible significant part of the immune system; after Splenectomy following trauma, the immune system changes; splenic autotransplantation can preserve the immune system after trauma and Splenectomy. BACKGROUND: Patients can be protected from immune dysfunction by autotransplanting splenic tissues after splenectomy following trauma because their immune systems and spleens are changed. Patients can gain their immune function after splenic autotransplantation. METHODS: Patient classification methods are into three categories, Group A, 6 cases with auto-translation; Group B, 6 cases without transplantation; Group C, seven regular people serving as the control. AIM OF WORK: The aim of the work is not to compare outcome methods or compare types of autotransplantation; This work aims to document postoperative radiological, immunological, clinical, and hematological investigations. We concentrated on the results of investigations more than the types of operation or approach or types of autotransplantation. RESULTS: We showed that, after comparing each group with normal individuals subjects, patients who did not undergo autotransplantation had significantly higher platelet counts, a more significant percentage of micronucleated reticulocytes, increased levels of naive B lymphocytes, changes in class-switched memory and class-unswitched memory B cells, and higher levels of PD1 on CD8 + T lymphocytes. Nevertheless, neither splenic autotransplant patients nor the average general population showed any appreciable variations in any of the parameters. CONCLUSIONS: Spleen’s activities with adequate hemocatheter activity and recovery of the immunological deficit after splenic autotransplantation.
format Online
Article
Text
id pubmed-10422790
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-104227902023-08-13 Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed Saad, Hassan A. Elsayed, Rasha S Riad, Mohamed El-Taher, Ahmed K. Eraky, Mohamed E Abdelmonem, Ashraf BMC Surg Research INTRODUCTION: The spleen is a responsible significant part of the immune system; after Splenectomy following trauma, the immune system changes; splenic autotransplantation can preserve the immune system after trauma and Splenectomy. BACKGROUND: Patients can be protected from immune dysfunction by autotransplanting splenic tissues after splenectomy following trauma because their immune systems and spleens are changed. Patients can gain their immune function after splenic autotransplantation. METHODS: Patient classification methods are into three categories, Group A, 6 cases with auto-translation; Group B, 6 cases without transplantation; Group C, seven regular people serving as the control. AIM OF WORK: The aim of the work is not to compare outcome methods or compare types of autotransplantation; This work aims to document postoperative radiological, immunological, clinical, and hematological investigations. We concentrated on the results of investigations more than the types of operation or approach or types of autotransplantation. RESULTS: We showed that, after comparing each group with normal individuals subjects, patients who did not undergo autotransplantation had significantly higher platelet counts, a more significant percentage of micronucleated reticulocytes, increased levels of naive B lymphocytes, changes in class-switched memory and class-unswitched memory B cells, and higher levels of PD1 on CD8 + T lymphocytes. Nevertheless, neither splenic autotransplant patients nor the average general population showed any appreciable variations in any of the parameters. CONCLUSIONS: Spleen’s activities with adequate hemocatheter activity and recovery of the immunological deficit after splenic autotransplantation. BioMed Central 2023-08-11 /pmc/articles/PMC10422790/ /pubmed/37568135 http://dx.doi.org/10.1186/s12893-023-02126-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Saad, Hassan A.
Elsayed, Rasha S
Riad, Mohamed
El-Taher, Ahmed K.
Eraky, Mohamed E
Abdelmonem, Ashraf
Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed
title Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed
title_full Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed
title_fullStr Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed
title_full_unstemmed Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed
title_short Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed
title_sort revitalize splenic functions. following a splenectomy for trauma, a small amount of splenic autotransplantation was performed
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422790/
https://www.ncbi.nlm.nih.gov/pubmed/37568135
http://dx.doi.org/10.1186/s12893-023-02126-z
work_keys_str_mv AT saadhassana revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed
AT elsayedrashas revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed
AT riadmohamed revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed
AT eltaherahmedk revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed
AT erakymohamede revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed
AT abdelmonemashraf revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed