Cargando…

Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017–2020

The platelet/high-density lipoprotein cholesterol ratio (PHR) is a novel inflammatory and hypercoagulability marker that represents the severity of metabolic syndrome. Liver metabolic syndrome is manifested by nonalcoholic fatty liver disease (NAFLD), which is associated with inflammation and hyperc...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Chun-feng, Cang, Xiao-min, Liu, Wang-shu, Wang, Li-hua, Huang, Hai-yan, Sang, Sheng-mei, Wang, Xue-qin, Fang, Xing-xing, Xu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422828/
https://www.ncbi.nlm.nih.gov/pubmed/37568178
http://dx.doi.org/10.1186/s12944-023-01861-9
_version_ 1785089309893722112
author Lu, Chun-feng
Cang, Xiao-min
Liu, Wang-shu
Wang, Li-hua
Huang, Hai-yan
Sang, Sheng-mei
Wang, Xue-qin
Fang, Xing-xing
Xu, Feng
author_facet Lu, Chun-feng
Cang, Xiao-min
Liu, Wang-shu
Wang, Li-hua
Huang, Hai-yan
Sang, Sheng-mei
Wang, Xue-qin
Fang, Xing-xing
Xu, Feng
author_sort Lu, Chun-feng
collection PubMed
description The platelet/high-density lipoprotein cholesterol ratio (PHR) is a novel inflammatory and hypercoagulability marker that represents the severity of metabolic syndrome. Liver metabolic syndrome is manifested by nonalcoholic fatty liver disease (NAFLD), which is associated with inflammation and hypercoagulability. This cross-sectional investigation aimed to identify the relationship between PHR and NAFLD. Participants in the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were evaluated for hepatic steatosis and fibrosis using vibration-controlled transient elastography. The PHR was calculated as the ratio of platelets to high-density lipoprotein cholesterol. Increased PHR was associated with an increased incidence of NAFLD and hepatic fibrosis. Compared with patients in the first PHR quartile, after adjustment for clinical variables, the corresponding odds ratio (OR) for NAFLD in the fourth quartile was 2.36 (95% CI, 1.76 to 3.18) (p < 0.05); however, the OR for hepatic fibrosis was not statistically significant (p > 0.05). Furthermore, restricted cubic spline analyses showed an S-shaped association between PHR and NAFLD and an L-shaped relationship between PHR and hepatic fibrosis. The results support the effectiveness of PHR as a marker for NAFLD and hepatic fibrosis. Therefore, interventions to improve the PHR may be of benefit in reducing the incidence of both hepatic steatosis and fibrosis.
format Online
Article
Text
id pubmed-10422828
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-104228282023-08-13 Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017–2020 Lu, Chun-feng Cang, Xiao-min Liu, Wang-shu Wang, Li-hua Huang, Hai-yan Sang, Sheng-mei Wang, Xue-qin Fang, Xing-xing Xu, Feng Lipids Health Dis Research The platelet/high-density lipoprotein cholesterol ratio (PHR) is a novel inflammatory and hypercoagulability marker that represents the severity of metabolic syndrome. Liver metabolic syndrome is manifested by nonalcoholic fatty liver disease (NAFLD), which is associated with inflammation and hypercoagulability. This cross-sectional investigation aimed to identify the relationship between PHR and NAFLD. Participants in the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were evaluated for hepatic steatosis and fibrosis using vibration-controlled transient elastography. The PHR was calculated as the ratio of platelets to high-density lipoprotein cholesterol. Increased PHR was associated with an increased incidence of NAFLD and hepatic fibrosis. Compared with patients in the first PHR quartile, after adjustment for clinical variables, the corresponding odds ratio (OR) for NAFLD in the fourth quartile was 2.36 (95% CI, 1.76 to 3.18) (p < 0.05); however, the OR for hepatic fibrosis was not statistically significant (p > 0.05). Furthermore, restricted cubic spline analyses showed an S-shaped association between PHR and NAFLD and an L-shaped relationship between PHR and hepatic fibrosis. The results support the effectiveness of PHR as a marker for NAFLD and hepatic fibrosis. Therefore, interventions to improve the PHR may be of benefit in reducing the incidence of both hepatic steatosis and fibrosis. BioMed Central 2023-08-11 /pmc/articles/PMC10422828/ /pubmed/37568178 http://dx.doi.org/10.1186/s12944-023-01861-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lu, Chun-feng
Cang, Xiao-min
Liu, Wang-shu
Wang, Li-hua
Huang, Hai-yan
Sang, Sheng-mei
Wang, Xue-qin
Fang, Xing-xing
Xu, Feng
Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017–2020
title Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017–2020
title_full Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017–2020
title_fullStr Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017–2020
title_full_unstemmed Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017–2020
title_short Association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from NHANES 2017–2020
title_sort association between the platelet/high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease: results from nhanes 2017–2020
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422828/
https://www.ncbi.nlm.nih.gov/pubmed/37568178
http://dx.doi.org/10.1186/s12944-023-01861-9
work_keys_str_mv AT luchunfeng associationbetweentheplatelethighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseresultsfromnhanes20172020
AT cangxiaomin associationbetweentheplatelethighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseresultsfromnhanes20172020
AT liuwangshu associationbetweentheplatelethighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseresultsfromnhanes20172020
AT wanglihua associationbetweentheplatelethighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseresultsfromnhanes20172020
AT huanghaiyan associationbetweentheplatelethighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseresultsfromnhanes20172020
AT sangshengmei associationbetweentheplatelethighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseresultsfromnhanes20172020
AT wangxueqin associationbetweentheplatelethighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseresultsfromnhanes20172020
AT fangxingxing associationbetweentheplatelethighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseresultsfromnhanes20172020
AT xufeng associationbetweentheplatelethighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseresultsfromnhanes20172020