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Computational design of Matrix Metalloproteinase-9 (MMP-9) resistant to auto-cleavage

Matrix metalloproteinase-9 (MMP-9) is an endopeptidase that remodels the extracellular matrix. MMP-9 has been implicated in several diseases including neurodegeneration, arthritis, cardiovascular diseases, fibrosis and several types of cancer, resulting in a high demand for MMP-9 inhibitors for ther...

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Detalles Bibliográficos
Autores principales:	Bonadio, Alessandro, Oguche, Solomon, Lavy, Tali, Kleifeld, Oded, Shifman, Julia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2023
Materias:	Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422929/ https://www.ncbi.nlm.nih.gov/pubmed/37401540 http://dx.doi.org/10.1042/BCJ20230139

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