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Changes in Oncological Surgical Principles Driven by Advances in Preoperative Treatments

From a surgical point of view, the development of preoperative oncological treatment has had a profound effect on the surgical treatment trends of cancer as well as on the outcomes of cancer patients. Consequently, these changes have challenged formerly entrenched oncological surgical principles. In...

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Autores principales: Horváth, Örs Péter, Bellyei, Szabolcs, Pozsgai, Éva, Vereczkei, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422972/
https://www.ncbi.nlm.nih.gov/pubmed/37575686
http://dx.doi.org/10.2147/TCRM.S415860
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author Horváth, Örs Péter
Bellyei, Szabolcs
Pozsgai, Éva
Vereczkei, András
author_facet Horváth, Örs Péter
Bellyei, Szabolcs
Pozsgai, Éva
Vereczkei, András
author_sort Horváth, Örs Péter
collection PubMed
description From a surgical point of view, the development of preoperative oncological treatment has had a profound effect on the surgical treatment trends of cancer as well as on the outcomes of cancer patients. Consequently, these changes have challenged formerly entrenched oncological surgical principles. In our short report, we aimed to summarize the main shifts regarding the surgical principles of cancer treatment due to the development of preoperative oncological therapy in recent years. As a result of successful preoperative treatment, surgeons may perform less radical surgeries, the required free resection margin has been narrowed down to a few millimeters in dimension and preoperative treatment is justified in both definitely resectable tumors and in oligometastatic tumors as well. For prognosis assessment, the post-preoperative oncological treatment stage is now considered decisive, rather than the pretreatment stage as previously thought. Other changes include the introduction of the watch and wait strategy and the reverse order of treatment of the primary tumor and metastasis. Observing the continuously improving outcomes of cancer patients and the developments in oncological treatment modalities, a further expansion of the indication of preoperative treatments is to be expected.
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spelling pubmed-104229722023-08-13 Changes in Oncological Surgical Principles Driven by Advances in Preoperative Treatments Horváth, Örs Péter Bellyei, Szabolcs Pozsgai, Éva Vereczkei, András Ther Clin Risk Manag Perspectives From a surgical point of view, the development of preoperative oncological treatment has had a profound effect on the surgical treatment trends of cancer as well as on the outcomes of cancer patients. Consequently, these changes have challenged formerly entrenched oncological surgical principles. In our short report, we aimed to summarize the main shifts regarding the surgical principles of cancer treatment due to the development of preoperative oncological therapy in recent years. As a result of successful preoperative treatment, surgeons may perform less radical surgeries, the required free resection margin has been narrowed down to a few millimeters in dimension and preoperative treatment is justified in both definitely resectable tumors and in oligometastatic tumors as well. For prognosis assessment, the post-preoperative oncological treatment stage is now considered decisive, rather than the pretreatment stage as previously thought. Other changes include the introduction of the watch and wait strategy and the reverse order of treatment of the primary tumor and metastasis. Observing the continuously improving outcomes of cancer patients and the developments in oncological treatment modalities, a further expansion of the indication of preoperative treatments is to be expected. Dove 2023-08-08 /pmc/articles/PMC10422972/ /pubmed/37575686 http://dx.doi.org/10.2147/TCRM.S415860 Text en © 2023 Horváth et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Perspectives
Horváth, Örs Péter
Bellyei, Szabolcs
Pozsgai, Éva
Vereczkei, András
Changes in Oncological Surgical Principles Driven by Advances in Preoperative Treatments
title Changes in Oncological Surgical Principles Driven by Advances in Preoperative Treatments
title_full Changes in Oncological Surgical Principles Driven by Advances in Preoperative Treatments
title_fullStr Changes in Oncological Surgical Principles Driven by Advances in Preoperative Treatments
title_full_unstemmed Changes in Oncological Surgical Principles Driven by Advances in Preoperative Treatments
title_short Changes in Oncological Surgical Principles Driven by Advances in Preoperative Treatments
title_sort changes in oncological surgical principles driven by advances in preoperative treatments
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422972/
https://www.ncbi.nlm.nih.gov/pubmed/37575686
http://dx.doi.org/10.2147/TCRM.S415860
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