Cargando…

Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy

Macrophages play a critical role in the immune response due to their ability to recognize and remove pathogens, as well as present antigens, which are involved in inflammation, but they are also one of the most abundant immune cell populations present in the tumor microenvironment. In recent years,...

Descripción completa

Detalles Bibliográficos
Autores principales: Wróblewska, Anna, Szczygieł, Agnieszka, Szermer-Olearnik, Bożena, Pajtasz-Piasecka, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422973/
https://www.ncbi.nlm.nih.gov/pubmed/37576466
http://dx.doi.org/10.2147/IJN.S421173
_version_ 1785089344889946112
author Wróblewska, Anna
Szczygieł, Agnieszka
Szermer-Olearnik, Bożena
Pajtasz-Piasecka, Elżbieta
author_facet Wróblewska, Anna
Szczygieł, Agnieszka
Szermer-Olearnik, Bożena
Pajtasz-Piasecka, Elżbieta
author_sort Wróblewska, Anna
collection PubMed
description Macrophages play a critical role in the immune response due to their ability to recognize and remove pathogens, as well as present antigens, which are involved in inflammation, but they are also one of the most abundant immune cell populations present in the tumor microenvironment. In recent years, macrophages have become promising cellular carriers for drug and nanoparticle delivery to the tumor microenvironment, mainly due to their natural properties such as biocompatibility, degradability, lack of immunogenicity, long half-life in circulation, crossing biological barriers, and the possibility of migration and accumulation at a site of inflammation such as a tumor. For the effectiveness of this therapeutic strategy, known as “Trojan horse”, it is important that the nanoparticles engulfed by macrophages do not affect their proper functioning. In our review, we discussed how the size, shape, chemical and mechanical properties of nanoparticles influence their internalization by macrophages. In addition, we described the promising research utilizing macrophages, their cell membranes and macrophage-derived exosomes as drug carriers in anticancer therapy. As a prospect of the wider use of this therapeutic strategy, we postulate its future application in boron delivery to the tumor environment in boron neutron capture therapy.
format Online
Article
Text
id pubmed-10422973
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-104229732023-08-13 Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy Wróblewska, Anna Szczygieł, Agnieszka Szermer-Olearnik, Bożena Pajtasz-Piasecka, Elżbieta Int J Nanomedicine Review Macrophages play a critical role in the immune response due to their ability to recognize and remove pathogens, as well as present antigens, which are involved in inflammation, but they are also one of the most abundant immune cell populations present in the tumor microenvironment. In recent years, macrophages have become promising cellular carriers for drug and nanoparticle delivery to the tumor microenvironment, mainly due to their natural properties such as biocompatibility, degradability, lack of immunogenicity, long half-life in circulation, crossing biological barriers, and the possibility of migration and accumulation at a site of inflammation such as a tumor. For the effectiveness of this therapeutic strategy, known as “Trojan horse”, it is important that the nanoparticles engulfed by macrophages do not affect their proper functioning. In our review, we discussed how the size, shape, chemical and mechanical properties of nanoparticles influence their internalization by macrophages. In addition, we described the promising research utilizing macrophages, their cell membranes and macrophage-derived exosomes as drug carriers in anticancer therapy. As a prospect of the wider use of this therapeutic strategy, we postulate its future application in boron delivery to the tumor environment in boron neutron capture therapy. Dove 2023-08-08 /pmc/articles/PMC10422973/ /pubmed/37576466 http://dx.doi.org/10.2147/IJN.S421173 Text en © 2023 Wróblewska et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Wróblewska, Anna
Szczygieł, Agnieszka
Szermer-Olearnik, Bożena
Pajtasz-Piasecka, Elżbieta
Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy
title Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy
title_full Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy
title_fullStr Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy
title_full_unstemmed Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy
title_short Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy
title_sort macrophages as promising carriers for nanoparticle delivery in anticancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10422973/
https://www.ncbi.nlm.nih.gov/pubmed/37576466
http://dx.doi.org/10.2147/IJN.S421173
work_keys_str_mv AT wroblewskaanna macrophagesaspromisingcarriersfornanoparticledeliveryinanticancertherapy
AT szczygiełagnieszka macrophagesaspromisingcarriersfornanoparticledeliveryinanticancertherapy
AT szermerolearnikbozena macrophagesaspromisingcarriersfornanoparticledeliveryinanticancertherapy
AT pajtaszpiaseckaelzbieta macrophagesaspromisingcarriersfornanoparticledeliveryinanticancertherapy