A Case of Ticagrelor-Induced Sinus Pause

Ticagrelor is an oral antiplatelet agent commonly used following percutaneous coronary intervention (PCI). There have been many reports describing bradyarrhythmias in the setting of ticagrelor use, most notably sinus pauses. This process is thought to be related to ticagrelor’s inhibition of human e...

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Detalles Bibliográficos
Autores principales: Pavlatos, Nicholas T, Shah, Aangi, Khan, Muhammad, Jaiswal, Vikash, Mattumpuram, Jishanth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423005/
https://www.ncbi.nlm.nih.gov/pubmed/37575834
http://dx.doi.org/10.7759/cureus.41821
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author Pavlatos, Nicholas T
Shah, Aangi
Khan, Muhammad
Jaiswal, Vikash
Mattumpuram, Jishanth
author_facet Pavlatos, Nicholas T
Shah, Aangi
Khan, Muhammad
Jaiswal, Vikash
Mattumpuram, Jishanth
author_sort Pavlatos, Nicholas T
collection PubMed
description Ticagrelor is an oral antiplatelet agent commonly used following percutaneous coronary intervention (PCI). There have been many reports describing bradyarrhythmias in the setting of ticagrelor use, most notably sinus pauses. This process is thought to be related to ticagrelor’s inhibition of human equilibrative nucleoside transporter (hENT1), which reduces cellular uptake of adenosine. We present a case of a 58-year-old male who experienced prolonged sinus pauses 38 hours after starting ticagrelor following ST-elevation myocardial infarction with subsequent PCI and stent placement.
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spelling pubmed-104230052023-08-13 A Case of Ticagrelor-Induced Sinus Pause Pavlatos, Nicholas T Shah, Aangi Khan, Muhammad Jaiswal, Vikash Mattumpuram, Jishanth Cureus Cardiology Ticagrelor is an oral antiplatelet agent commonly used following percutaneous coronary intervention (PCI). There have been many reports describing bradyarrhythmias in the setting of ticagrelor use, most notably sinus pauses. This process is thought to be related to ticagrelor’s inhibition of human equilibrative nucleoside transporter (hENT1), which reduces cellular uptake of adenosine. We present a case of a 58-year-old male who experienced prolonged sinus pauses 38 hours after starting ticagrelor following ST-elevation myocardial infarction with subsequent PCI and stent placement. Cureus 2023-07-13 /pmc/articles/PMC10423005/ /pubmed/37575834 http://dx.doi.org/10.7759/cureus.41821 Text en Copyright © 2023, Pavlatos et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Pavlatos, Nicholas T
Shah, Aangi
Khan, Muhammad
Jaiswal, Vikash
Mattumpuram, Jishanth
A Case of Ticagrelor-Induced Sinus Pause
title A Case of Ticagrelor-Induced Sinus Pause
title_full A Case of Ticagrelor-Induced Sinus Pause
title_fullStr A Case of Ticagrelor-Induced Sinus Pause
title_full_unstemmed A Case of Ticagrelor-Induced Sinus Pause
title_short A Case of Ticagrelor-Induced Sinus Pause
title_sort case of ticagrelor-induced sinus pause
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423005/
https://www.ncbi.nlm.nih.gov/pubmed/37575834
http://dx.doi.org/10.7759/cureus.41821
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