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High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients

INTRODUCTION: Head and neck squamous cell carcinoma (HNSCC) is among the most common cancers in the world with a low survival rate and common diagnosis at late stages. Deubiquitination of proteins is involved in tumor growth, metastasis, apoptosis, and immunosuppressive pathways. The impact of the u...

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Autores principales: Scheiflinger, Alexandra, Al-Gboore, Sega, Jank, Bernhard J., Brkic, Faris, Kadletz-Wanke, Lorenz, Kenner, Lukas, Heiduschka, Gregor, Schnoell, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423105/
https://www.ncbi.nlm.nih.gov/pubmed/37308746
http://dx.doi.org/10.1007/s00432-023-04872-2
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author Scheiflinger, Alexandra
Al-Gboore, Sega
Jank, Bernhard J.
Brkic, Faris
Kadletz-Wanke, Lorenz
Kenner, Lukas
Heiduschka, Gregor
Schnoell, Julia
author_facet Scheiflinger, Alexandra
Al-Gboore, Sega
Jank, Bernhard J.
Brkic, Faris
Kadletz-Wanke, Lorenz
Kenner, Lukas
Heiduschka, Gregor
Schnoell, Julia
author_sort Scheiflinger, Alexandra
collection PubMed
description INTRODUCTION: Head and neck squamous cell carcinoma (HNSCC) is among the most common cancers in the world with a low survival rate and common diagnosis at late stages. Deubiquitination of proteins is involved in tumor growth, metastasis, apoptosis, and immunosuppressive pathways. The impact of the ubiquitin-specific protease (USP4) on survival was only scarcely investigated so far. The goal of our research was to analyze the association of USP4 expression with prognosis and clinicopathological features in HNSCC. METHODS: USP4 mRNA levels were derived from The Cancer Genome Atlas (TCGA) for a cohort of 510 patients. Protein expression of USP4 was analyzed by immunohistochemistry in a second cohort of 113 patients. Associations between USP4 levels and overall survival, disease-free survival and clinicopathological data were analyzed. RESULTS: High levels of USP4 mRNA were associated with prolonged overall survival in univariable analysis. There was no more association with survival after correction for the confounders HPV, stage and smoker status. High USP4 mRNA levels were linked to a lower T-stage, the patient’s age at diagnosis, and a positive HPV status. USP4 protein levels were not associated with prognosis or other features. CONCLUSION: Since high USP4 mRNA was not an independent prognostic marker, we assume that the association is a result of the correlation of high USP4 mRNA with an HPV-positive status. Therefore, further investigation of USP4 mRNA and its association with the HPV status of HNSCC patients is warranted.
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spelling pubmed-104231052023-08-14 High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients Scheiflinger, Alexandra Al-Gboore, Sega Jank, Bernhard J. Brkic, Faris Kadletz-Wanke, Lorenz Kenner, Lukas Heiduschka, Gregor Schnoell, Julia J Cancer Res Clin Oncol Research INTRODUCTION: Head and neck squamous cell carcinoma (HNSCC) is among the most common cancers in the world with a low survival rate and common diagnosis at late stages. Deubiquitination of proteins is involved in tumor growth, metastasis, apoptosis, and immunosuppressive pathways. The impact of the ubiquitin-specific protease (USP4) on survival was only scarcely investigated so far. The goal of our research was to analyze the association of USP4 expression with prognosis and clinicopathological features in HNSCC. METHODS: USP4 mRNA levels were derived from The Cancer Genome Atlas (TCGA) for a cohort of 510 patients. Protein expression of USP4 was analyzed by immunohistochemistry in a second cohort of 113 patients. Associations between USP4 levels and overall survival, disease-free survival and clinicopathological data were analyzed. RESULTS: High levels of USP4 mRNA were associated with prolonged overall survival in univariable analysis. There was no more association with survival after correction for the confounders HPV, stage and smoker status. High USP4 mRNA levels were linked to a lower T-stage, the patient’s age at diagnosis, and a positive HPV status. USP4 protein levels were not associated with prognosis or other features. CONCLUSION: Since high USP4 mRNA was not an independent prognostic marker, we assume that the association is a result of the correlation of high USP4 mRNA with an HPV-positive status. Therefore, further investigation of USP4 mRNA and its association with the HPV status of HNSCC patients is warranted. Springer Berlin Heidelberg 2023-06-12 2023 /pmc/articles/PMC10423105/ /pubmed/37308746 http://dx.doi.org/10.1007/s00432-023-04872-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Scheiflinger, Alexandra
Al-Gboore, Sega
Jank, Bernhard J.
Brkic, Faris
Kadletz-Wanke, Lorenz
Kenner, Lukas
Heiduschka, Gregor
Schnoell, Julia
High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients
title High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients
title_full High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients
title_fullStr High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients
title_full_unstemmed High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients
title_short High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients
title_sort high usp4 mrna is associated with an hpv-positive status in head and neck squamous cell carcinoma patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423105/
https://www.ncbi.nlm.nih.gov/pubmed/37308746
http://dx.doi.org/10.1007/s00432-023-04872-2
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