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Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma

Ubiquitination is a reversible process that not only controls protein synthesis and degradation, but also is essential for protein transport, localization and biological activity. Deubiquitinating enzyme (DUB) dysfunction leads to various diseases, including cancer. In this study, we aimed to explor...

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Autores principales: Wu, Yue, Duan, Yuansheng, Han, Wei, Cao, Jiayan, Ye, Beibei, Chen, Peng, Li, Hong, Wang, Yuxuan, Liu, Jin, Fang, Yan, Yue, Kai, Wu, Yansheng, Wang, Xudong, Jing, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423255/
https://www.ncbi.nlm.nih.gov/pubmed/37573347
http://dx.doi.org/10.1038/s41419-023-06035-0
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author Wu, Yue
Duan, Yuansheng
Han, Wei
Cao, Jiayan
Ye, Beibei
Chen, Peng
Li, Hong
Wang, Yuxuan
Liu, Jin
Fang, Yan
Yue, Kai
Wu, Yansheng
Wang, Xudong
Jing, Chao
author_facet Wu, Yue
Duan, Yuansheng
Han, Wei
Cao, Jiayan
Ye, Beibei
Chen, Peng
Li, Hong
Wang, Yuxuan
Liu, Jin
Fang, Yan
Yue, Kai
Wu, Yansheng
Wang, Xudong
Jing, Chao
author_sort Wu, Yue
collection PubMed
description Ubiquitination is a reversible process that not only controls protein synthesis and degradation, but also is essential for protein transport, localization and biological activity. Deubiquitinating enzyme (DUB) dysfunction leads to various diseases, including cancer. In this study, we aimed to explore the functions and mechanisms of crucial DUBs in head and neck squamous cell carcinoma (HNSCC). Based on bioinformatic analysis and immunohistochemistry detection, YOD1 was identified to be significantly downregulated in HNSCC specimens compared with adjacent normal tissues. Further analysis revealed that reduced YOD1 expression was associated with the malignant progression of HNSCC and indicated poor prognosis. The results of the in vitro and in vivo experiments verified that YOD1 depletion significantly promoted growth, invasion, and epithelial-mesenchymal transition in HNSCC. Mechanistically, YOD1 inhibited the activation of the ERK/β-catenin pathway by suppressing the ubiquitination and degradation of TRIM33, leading to the constriction of HNSCC progression. Overall, our findings reveal the molecular mechanism underlying the role of YOD1 in tumor progression and provide a novel potential therapeutic target for HNSCC treatment.
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spelling pubmed-104232552023-08-14 Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma Wu, Yue Duan, Yuansheng Han, Wei Cao, Jiayan Ye, Beibei Chen, Peng Li, Hong Wang, Yuxuan Liu, Jin Fang, Yan Yue, Kai Wu, Yansheng Wang, Xudong Jing, Chao Cell Death Dis Article Ubiquitination is a reversible process that not only controls protein synthesis and degradation, but also is essential for protein transport, localization and biological activity. Deubiquitinating enzyme (DUB) dysfunction leads to various diseases, including cancer. In this study, we aimed to explore the functions and mechanisms of crucial DUBs in head and neck squamous cell carcinoma (HNSCC). Based on bioinformatic analysis and immunohistochemistry detection, YOD1 was identified to be significantly downregulated in HNSCC specimens compared with adjacent normal tissues. Further analysis revealed that reduced YOD1 expression was associated with the malignant progression of HNSCC and indicated poor prognosis. The results of the in vitro and in vivo experiments verified that YOD1 depletion significantly promoted growth, invasion, and epithelial-mesenchymal transition in HNSCC. Mechanistically, YOD1 inhibited the activation of the ERK/β-catenin pathway by suppressing the ubiquitination and degradation of TRIM33, leading to the constriction of HNSCC progression. Overall, our findings reveal the molecular mechanism underlying the role of YOD1 in tumor progression and provide a novel potential therapeutic target for HNSCC treatment. Nature Publishing Group UK 2023-08-12 /pmc/articles/PMC10423255/ /pubmed/37573347 http://dx.doi.org/10.1038/s41419-023-06035-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wu, Yue
Duan, Yuansheng
Han, Wei
Cao, Jiayan
Ye, Beibei
Chen, Peng
Li, Hong
Wang, Yuxuan
Liu, Jin
Fang, Yan
Yue, Kai
Wu, Yansheng
Wang, Xudong
Jing, Chao
Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma
title Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma
title_full Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma
title_fullStr Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma
title_full_unstemmed Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma
title_short Deubiquitinase YOD1 suppresses tumor progression by stabilizing E3 ligase TRIM33 in head and neck squamous cell carcinoma
title_sort deubiquitinase yod1 suppresses tumor progression by stabilizing e3 ligase trim33 in head and neck squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423255/
https://www.ncbi.nlm.nih.gov/pubmed/37573347
http://dx.doi.org/10.1038/s41419-023-06035-0
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