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Decreased cyclooxygenase-2 associated with impaired megakaryopoiesis and thrombopoiesis in primary immune thrombocytopenia

BACKGROUND: Cyclooxygenase (COX)-2 is a rate-limiting enzyme in the biosynthesis of prostanoids, which is mostly inducible by inflammatory cytokines. The participation of COX-2 in the maturation of megakaryocytes has been reported but barely studied in primary immune thrombocytopenia (ITP). METHODS:...

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Detalles Bibliográficos
Autores principales:	Zhuang, Xibing, Xu, Pengcheng, Ou, Yang, Shao, Xia, Li, Ying, Ma, Yanna, Qin, Shanshan, Hua, Fanli, Zhan, Yanxia, Ji, Lili, Qiao, Tiankui, Chen, Hao, Cheng, Yunfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423426/ https://www.ncbi.nlm.nih.gov/pubmed/37573325 http://dx.doi.org/10.1186/s12967-023-04389-9

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