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Impact of semen oxidative stress on sperm quality: initial results from Vietnam

OBJECTIVES: This study aimed to determine the relationship between oxidative stress (OS) measured by the oxidation–reduction potential (ORP) and the results of semen analysis among men from infertile couples. METHODS: This cross-sectional study included 166 men from infertile couples, determined acc...

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Detalles Bibliográficos
Autores principales: Nguyen, Nguyen Dac, Le, Minh Tam, Dang, Hong Nhan Thi, Van Nguyen, Trung, Nguyen, Quoc Huy Vu, Cao, Thanh Ngoc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423449/
https://www.ncbi.nlm.nih.gov/pubmed/37572034
http://dx.doi.org/10.1177/03000605231188655
Descripción
Sumario:OBJECTIVES: This study aimed to determine the relationship between oxidative stress (OS) measured by the oxidation–reduction potential (ORP) and the results of semen analysis among men from infertile couples. METHODS: This cross-sectional study included 166 men from infertile couples, determined according to the World Health Organization guidelines. The general characteristics, semen analysis, sperm chromatin dispersion assay, and ORP of all subjects were evaluated and analyzed statistically. RESULTS: Among 166 men from infertile couples, individuals with OS had a significantly higher DNA fragmentation index (DFI) than men without OS (22.37% ± 11.67% vs. 17.98% ± 8.98%). The sperm concentration, total sperm count, motility rate, and normal morphology were negatively correlated, while and an abnormal head and neck–tail were positively correlated with ORP. There was also a positive association between the DFI and OS level. The optimal ORP threshold for determining sperm quality was 0.77 mV/10(6) sperm/mL (sensitivity, 50.4%; specificity, 93.5%; positive predictive value, 52.9%; negative predictive value, 32.3%). CONCLUSIONS: Determining the ORP suggests that OS has an adverse effect on the total sperm count, sperm motility, sperm concentration, morphology, vitality, and DNA fragmentation index.