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Impact of semen oxidative stress on sperm quality: initial results from Vietnam
OBJECTIVES: This study aimed to determine the relationship between oxidative stress (OS) measured by the oxidation–reduction potential (ORP) and the results of semen analysis among men from infertile couples. METHODS: This cross-sectional study included 166 men from infertile couples, determined acc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423449/ https://www.ncbi.nlm.nih.gov/pubmed/37572034 http://dx.doi.org/10.1177/03000605231188655 |
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author | Nguyen, Nguyen Dac Le, Minh Tam Dang, Hong Nhan Thi Van Nguyen, Trung Nguyen, Quoc Huy Vu Cao, Thanh Ngoc |
author_facet | Nguyen, Nguyen Dac Le, Minh Tam Dang, Hong Nhan Thi Van Nguyen, Trung Nguyen, Quoc Huy Vu Cao, Thanh Ngoc |
author_sort | Nguyen, Nguyen Dac |
collection | PubMed |
description | OBJECTIVES: This study aimed to determine the relationship between oxidative stress (OS) measured by the oxidation–reduction potential (ORP) and the results of semen analysis among men from infertile couples. METHODS: This cross-sectional study included 166 men from infertile couples, determined according to the World Health Organization guidelines. The general characteristics, semen analysis, sperm chromatin dispersion assay, and ORP of all subjects were evaluated and analyzed statistically. RESULTS: Among 166 men from infertile couples, individuals with OS had a significantly higher DNA fragmentation index (DFI) than men without OS (22.37% ± 11.67% vs. 17.98% ± 8.98%). The sperm concentration, total sperm count, motility rate, and normal morphology were negatively correlated, while and an abnormal head and neck–tail were positively correlated with ORP. There was also a positive association between the DFI and OS level. The optimal ORP threshold for determining sperm quality was 0.77 mV/10(6) sperm/mL (sensitivity, 50.4%; specificity, 93.5%; positive predictive value, 52.9%; negative predictive value, 32.3%). CONCLUSIONS: Determining the ORP suggests that OS has an adverse effect on the total sperm count, sperm motility, sperm concentration, morphology, vitality, and DNA fragmentation index. |
format | Online Article Text |
id | pubmed-10423449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-104234492023-08-14 Impact of semen oxidative stress on sperm quality: initial results from Vietnam Nguyen, Nguyen Dac Le, Minh Tam Dang, Hong Nhan Thi Van Nguyen, Trung Nguyen, Quoc Huy Vu Cao, Thanh Ngoc J Int Med Res Pre-Clinical Research Report OBJECTIVES: This study aimed to determine the relationship between oxidative stress (OS) measured by the oxidation–reduction potential (ORP) and the results of semen analysis among men from infertile couples. METHODS: This cross-sectional study included 166 men from infertile couples, determined according to the World Health Organization guidelines. The general characteristics, semen analysis, sperm chromatin dispersion assay, and ORP of all subjects were evaluated and analyzed statistically. RESULTS: Among 166 men from infertile couples, individuals with OS had a significantly higher DNA fragmentation index (DFI) than men without OS (22.37% ± 11.67% vs. 17.98% ± 8.98%). The sperm concentration, total sperm count, motility rate, and normal morphology were negatively correlated, while and an abnormal head and neck–tail were positively correlated with ORP. There was also a positive association between the DFI and OS level. The optimal ORP threshold for determining sperm quality was 0.77 mV/10(6) sperm/mL (sensitivity, 50.4%; specificity, 93.5%; positive predictive value, 52.9%; negative predictive value, 32.3%). CONCLUSIONS: Determining the ORP suggests that OS has an adverse effect on the total sperm count, sperm motility, sperm concentration, morphology, vitality, and DNA fragmentation index. SAGE Publications 2023-08-12 /pmc/articles/PMC10423449/ /pubmed/37572034 http://dx.doi.org/10.1177/03000605231188655 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Pre-Clinical Research Report Nguyen, Nguyen Dac Le, Minh Tam Dang, Hong Nhan Thi Van Nguyen, Trung Nguyen, Quoc Huy Vu Cao, Thanh Ngoc Impact of semen oxidative stress on sperm quality: initial results from Vietnam |
title | Impact of semen oxidative stress on sperm quality: initial results from Vietnam |
title_full | Impact of semen oxidative stress on sperm quality: initial results from Vietnam |
title_fullStr | Impact of semen oxidative stress on sperm quality: initial results from Vietnam |
title_full_unstemmed | Impact of semen oxidative stress on sperm quality: initial results from Vietnam |
title_short | Impact of semen oxidative stress on sperm quality: initial results from Vietnam |
title_sort | impact of semen oxidative stress on sperm quality: initial results from vietnam |
topic | Pre-Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423449/ https://www.ncbi.nlm.nih.gov/pubmed/37572034 http://dx.doi.org/10.1177/03000605231188655 |
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