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Effects of the CYP3A inhibitors, voriconazole, itraconazole, and fluconazole on the pharmacokinetics of osimertinib in rats

BACKGROUND: Osimertinib, as third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment approved to treat advanced T790M mutation-positive tumors. Triazole antifungals are therapeutic drugs for cancer patients to reduce the risk of opportunisti...

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Detalles Bibliográficos
Autores principales:	Lou, Yutao, Song, Feifeng, Cheng, Mengting, Hu, Ying, Chai, Yitao, Hu, Qing, Wang, Qiyue, Zhou, Hongying, Bao, Meihua, Gu, Jinping, Zhang, Yiwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2023
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423561/ https://www.ncbi.nlm.nih.gov/pubmed/37581117 http://dx.doi.org/10.7717/peerj.15844

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