Keloids After Herpes Zoster: Report of Wolf’s Isotopic Phenomenon and Literature Review

Wolf’s isotopic response (WIR) refers to the appearance of a new skin disorder at the exact site of an unrelated skin disorder that had previously been cured. The most common primary skin disease in which WIR occurs is herpes zoster. Despite numerous theories being put forward to explain this occurrence, including viral, vascular, immunological, and neurological hypotheses, the pathogenesis of WIR after herpes zoster remains unclear. We report the case of a 76-year-old patient who presented with keloids at the site of the original herpes zoster. Based on this observation and a review of the literature, The clinical characteristics and possible theoretical reasons for keloids after herpes zoster will be discussed.