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Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review
INTRODUCTION: Bowen’s disease (BD) commonly occurs in sites of chronic sunlight exposure such as head, neck and extremities. It rarely distributes on the nipple and areola. CASE PRESENTATION: A 59-year-old female presented with crusted plaque on the right breast for over 1 month. Physical examinatio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423580/ https://www.ncbi.nlm.nih.gov/pubmed/37581009 http://dx.doi.org/10.2147/CCID.S419059 |
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author | Zhang, Guiyun Lu, Yufeng Liu, Bin Wang, Yanmei Li, Wenyi Xu, Yangchun |
author_facet | Zhang, Guiyun Lu, Yufeng Liu, Bin Wang, Yanmei Li, Wenyi Xu, Yangchun |
author_sort | Zhang, Guiyun |
collection | PubMed |
description | INTRODUCTION: Bowen’s disease (BD) commonly occurs in sites of chronic sunlight exposure such as head, neck and extremities. It rarely distributes on the nipple and areola. CASE PRESENTATION: A 59-year-old female presented with crusted plaque on the right breast for over 1 month. Physical examination found an asymptomatic plaque (5 cm × 5 cm) with irregular shape on the right breast. Histopathological examination suggested irregularly acanthotic epidermis and atypical epidermal cells. Dermis showed inflammatory cell infiltration. Immunohistochemical staining showed negative staining for cytokeratin 7 and cytokeratin 20, and positive staining for Ki67 (60%). The mass was excised and no recurrence occurred in the follow-up. Additionally, we reviewed the literature about BD of the breast and summarized the clinical manifestations, histological features, and treatment options. CONCLUSION: We reported a rare BD case involving nipple and areola. Wide local excision and complete nipple excision are effective for patients with BD of the nipple and areola. |
format | Online Article Text |
id | pubmed-10423580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-104235802023-08-14 Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review Zhang, Guiyun Lu, Yufeng Liu, Bin Wang, Yanmei Li, Wenyi Xu, Yangchun Clin Cosmet Investig Dermatol Case Report INTRODUCTION: Bowen’s disease (BD) commonly occurs in sites of chronic sunlight exposure such as head, neck and extremities. It rarely distributes on the nipple and areola. CASE PRESENTATION: A 59-year-old female presented with crusted plaque on the right breast for over 1 month. Physical examination found an asymptomatic plaque (5 cm × 5 cm) with irregular shape on the right breast. Histopathological examination suggested irregularly acanthotic epidermis and atypical epidermal cells. Dermis showed inflammatory cell infiltration. Immunohistochemical staining showed negative staining for cytokeratin 7 and cytokeratin 20, and positive staining for Ki67 (60%). The mass was excised and no recurrence occurred in the follow-up. Additionally, we reviewed the literature about BD of the breast and summarized the clinical manifestations, histological features, and treatment options. CONCLUSION: We reported a rare BD case involving nipple and areola. Wide local excision and complete nipple excision are effective for patients with BD of the nipple and areola. Dove 2023-08-09 /pmc/articles/PMC10423580/ /pubmed/37581009 http://dx.doi.org/10.2147/CCID.S419059 Text en © 2023 Zhang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Case Report Zhang, Guiyun Lu, Yufeng Liu, Bin Wang, Yanmei Li, Wenyi Xu, Yangchun Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review |
title | Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review |
title_full | Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review |
title_fullStr | Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review |
title_full_unstemmed | Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review |
title_short | Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review |
title_sort | bowen’s disease of the nipple and areola: case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423580/ https://www.ncbi.nlm.nih.gov/pubmed/37581009 http://dx.doi.org/10.2147/CCID.S419059 |
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