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Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review

INTRODUCTION: Bowen’s disease (BD) commonly occurs in sites of chronic sunlight exposure such as head, neck and extremities. It rarely distributes on the nipple and areola. CASE PRESENTATION: A 59-year-old female presented with crusted plaque on the right breast for over 1 month. Physical examinatio...

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Autores principales: Zhang, Guiyun, Lu, Yufeng, Liu, Bin, Wang, Yanmei, Li, Wenyi, Xu, Yangchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423580/
https://www.ncbi.nlm.nih.gov/pubmed/37581009
http://dx.doi.org/10.2147/CCID.S419059
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author Zhang, Guiyun
Lu, Yufeng
Liu, Bin
Wang, Yanmei
Li, Wenyi
Xu, Yangchun
author_facet Zhang, Guiyun
Lu, Yufeng
Liu, Bin
Wang, Yanmei
Li, Wenyi
Xu, Yangchun
author_sort Zhang, Guiyun
collection PubMed
description INTRODUCTION: Bowen’s disease (BD) commonly occurs in sites of chronic sunlight exposure such as head, neck and extremities. It rarely distributes on the nipple and areola. CASE PRESENTATION: A 59-year-old female presented with crusted plaque on the right breast for over 1 month. Physical examination found an asymptomatic plaque (5 cm × 5 cm) with irregular shape on the right breast. Histopathological examination suggested irregularly acanthotic epidermis and atypical epidermal cells. Dermis showed inflammatory cell infiltration. Immunohistochemical staining showed negative staining for cytokeratin 7 and cytokeratin 20, and positive staining for Ki67 (60%). The mass was excised and no recurrence occurred in the follow-up. Additionally, we reviewed the literature about BD of the breast and summarized the clinical manifestations, histological features, and treatment options. CONCLUSION: We reported a rare BD case involving nipple and areola. Wide local excision and complete nipple excision are effective for patients with BD of the nipple and areola.
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spelling pubmed-104235802023-08-14 Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review Zhang, Guiyun Lu, Yufeng Liu, Bin Wang, Yanmei Li, Wenyi Xu, Yangchun Clin Cosmet Investig Dermatol Case Report INTRODUCTION: Bowen’s disease (BD) commonly occurs in sites of chronic sunlight exposure such as head, neck and extremities. It rarely distributes on the nipple and areola. CASE PRESENTATION: A 59-year-old female presented with crusted plaque on the right breast for over 1 month. Physical examination found an asymptomatic plaque (5 cm × 5 cm) with irregular shape on the right breast. Histopathological examination suggested irregularly acanthotic epidermis and atypical epidermal cells. Dermis showed inflammatory cell infiltration. Immunohistochemical staining showed negative staining for cytokeratin 7 and cytokeratin 20, and positive staining for Ki67 (60%). The mass was excised and no recurrence occurred in the follow-up. Additionally, we reviewed the literature about BD of the breast and summarized the clinical manifestations, histological features, and treatment options. CONCLUSION: We reported a rare BD case involving nipple and areola. Wide local excision and complete nipple excision are effective for patients with BD of the nipple and areola. Dove 2023-08-09 /pmc/articles/PMC10423580/ /pubmed/37581009 http://dx.doi.org/10.2147/CCID.S419059 Text en © 2023 Zhang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Zhang, Guiyun
Lu, Yufeng
Liu, Bin
Wang, Yanmei
Li, Wenyi
Xu, Yangchun
Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review
title Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review
title_full Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review
title_fullStr Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review
title_full_unstemmed Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review
title_short Bowen’s Disease of the Nipple and Areola: Case Report and Literature Review
title_sort bowen’s disease of the nipple and areola: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423580/
https://www.ncbi.nlm.nih.gov/pubmed/37581009
http://dx.doi.org/10.2147/CCID.S419059
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