Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater

Acinetobacter baumannii is an opportunistic pathogen that is mostly associated with hospital-acquired infections. The rapid emergence of multi- and pan-drug-resistant Acinetobacter strains poses an increasing challenge in hospitals. Phage therapy offers one treatment option for infections caused by...

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Autores principales: Kolsi, Anna, Haukka, Kaisa, Dougnon, Victorien, Agbankpè, Alidehou Jerrold, Fabiyi, Kafayath, Virta, Marko, Skurnik, Mikael, Kantele, Anu, Kiljunen, Saija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423700/
https://www.ncbi.nlm.nih.gov/pubmed/37574509
http://dx.doi.org/10.1007/s00705-023-05845-z
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author Kolsi, Anna
Haukka, Kaisa
Dougnon, Victorien
Agbankpè, Alidehou Jerrold
Fabiyi, Kafayath
Virta, Marko
Skurnik, Mikael
Kantele, Anu
Kiljunen, Saija
author_facet Kolsi, Anna
Haukka, Kaisa
Dougnon, Victorien
Agbankpè, Alidehou Jerrold
Fabiyi, Kafayath
Virta, Marko
Skurnik, Mikael
Kantele, Anu
Kiljunen, Saija
author_sort Kolsi, Anna
collection PubMed
description Acinetobacter baumannii is an opportunistic pathogen that is mostly associated with hospital-acquired infections. The rapid emergence of multi- and pan-drug-resistant Acinetobacter strains poses an increasing challenge in hospitals. Phage therapy offers one treatment option for infections caused by A. baumannii. We isolated three phages from Beninese hospital wastewater – fBenAci001, fBenAci002, and fBenAci003 – that infected clinical A. baumannii strains from Finnish patients. Phylogenetic analysis showed that these phages resemble phages of the genus Friunavirus, family Autographiviridae. The isolated phages meet the requirements set for phages used for phage therapy. However, they were found to have a narrow host range, which may limit their therapeutic use. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-023-05845-z.
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spelling pubmed-104237002023-08-15 Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater Kolsi, Anna Haukka, Kaisa Dougnon, Victorien Agbankpè, Alidehou Jerrold Fabiyi, Kafayath Virta, Marko Skurnik, Mikael Kantele, Anu Kiljunen, Saija Arch Virol Brief Report Acinetobacter baumannii is an opportunistic pathogen that is mostly associated with hospital-acquired infections. The rapid emergence of multi- and pan-drug-resistant Acinetobacter strains poses an increasing challenge in hospitals. Phage therapy offers one treatment option for infections caused by A. baumannii. We isolated three phages from Beninese hospital wastewater – fBenAci001, fBenAci002, and fBenAci003 – that infected clinical A. baumannii strains from Finnish patients. Phylogenetic analysis showed that these phages resemble phages of the genus Friunavirus, family Autographiviridae. The isolated phages meet the requirements set for phages used for phage therapy. However, they were found to have a narrow host range, which may limit their therapeutic use. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-023-05845-z. Springer Vienna 2023-08-13 2023 /pmc/articles/PMC10423700/ /pubmed/37574509 http://dx.doi.org/10.1007/s00705-023-05845-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Kolsi, Anna
Haukka, Kaisa
Dougnon, Victorien
Agbankpè, Alidehou Jerrold
Fabiyi, Kafayath
Virta, Marko
Skurnik, Mikael
Kantele, Anu
Kiljunen, Saija
Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater
title Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater
title_full Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater
title_fullStr Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater
title_full_unstemmed Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater
title_short Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater
title_sort isolation and characterization of three novel acinetobacter baumannii phages from beninese hospital wastewater
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423700/
https://www.ncbi.nlm.nih.gov/pubmed/37574509
http://dx.doi.org/10.1007/s00705-023-05845-z
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