Identification of renal cyst cells of type I Nephronophthisis by single-nucleus RNA sequencing

Background: Nephronophthisis (NPH) is the most common genetic cause of end-stage renal disease (ESRD) in childhood, and NPHP1 is the major pathogenic gene. Cyst formation at the corticomedullary junction is a pathological feature of NPH, but the mechanism underlying cystogenesis is not well understo...

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Detalles Bibliográficos
Autores principales: Wang, Qianying, Zou, Baojuan, Wei, Xiaoya, Lin, Hongrong, Pang, Changmiao, Wang, Lei, Zhong, Jinglin, Chen, Huamu, Gao, Xuefei, Li, Min, Ong, Albert C. M., Yue, Zhihui, Sun, Liangzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423821/
https://www.ncbi.nlm.nih.gov/pubmed/37583898
http://dx.doi.org/10.3389/fcell.2023.1192935

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