Partial genome content within rAAVs impacts performance in a cell assay-dependent manner

Recombinant adeno-associated viruses (rAAVs) deliver DNA to numerous cell types. However, packaging of partial genomes into the rAAV capsid is of concern. Although empty rAAV capsids are studied, there is little information regarding the impact of partial DNA content on rAAV performance in controlle...

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Detalles Bibliográficos
Autores principales: Troxell, Bryan, Jaslow, Sarah L., Tsai, I-Wei, Sullivan, Chelsea, Draper, Benjamin E., Jarrold, Martin F., Lindsey, Kate, Blue, Levi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423999/
https://www.ncbi.nlm.nih.gov/pubmed/37583716
http://dx.doi.org/10.1016/j.omtm.2023.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423999/
https://www.ncbi.nlm.nih.gov/pubmed/37583716
http://dx.doi.org/10.1016/j.omtm.2023.07.007

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