Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells

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Discrimination between hematopoietic stem cells and leukemic stem cells remains a major challenge for acute myeloid leukemia immunotherapy. CAR T cells specific for the CD117 antigen can deplete malignant and healthy hematopoietic stem cells before consolidation with allogeneic hematopoietic stem ce...

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Detalles Bibliográficos
Autores principales: Magnani, Chiara F., Myburgh, Renier, Brunn, Silvan, Chambovey, Morgane, Ponzo, Marianna, Volta, Laura, Manfredi, Francesco, Pellegrino, Christian, Pascolo, Steve, Miskey, Csaba, Ivics, Zoltán, Shizuru, Judith A., Neri, Dario, Manz, Markus G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424000/
https://www.ncbi.nlm.nih.gov/pubmed/37583386
http://dx.doi.org/10.1016/j.omto.2023.07.003

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