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Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report
BACKGROUND: Pulmonary alveolar proteinosis (PAP) often presents nonspecifically and can be easily confused with: (1) Idiopathic interstitial lung fibrosis; (2) alveolar carcinoma; (3) pulmonary tuberculosis; and (4) other lung diseases such as viral pneumonia, mycoplasma pneumonia, and chlamydial pn...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424030/ https://www.ncbi.nlm.nih.gov/pubmed/37583994 http://dx.doi.org/10.12998/wjcc.v11.i20.4932 |
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author | Jian, Li Zhao, Qi-Quan |
author_facet | Jian, Li Zhao, Qi-Quan |
author_sort | Jian, Li |
collection | PubMed |
description | BACKGROUND: Pulmonary alveolar proteinosis (PAP) often presents nonspecifically and can be easily confused with: (1) Idiopathic interstitial lung fibrosis; (2) alveolar carcinoma; (3) pulmonary tuberculosis; and (4) other lung diseases such as viral pneumonia, mycoplasma pneumonia, and chlamydial pneumonia. CASE SUMMARY: Diagnosis: In this case, a patient was diagnosed with PAP through transbronchial cryobiopsy (TBCB) and quantitative metagenomic next-generation sequencing, which confirmed the impairment of surfactant turnover as the underlying cause of PAP. Interventions: High-volume total lung lavage was performed for this patient. Outcomes: The patient's clinical condition had improved significantly by the 6-month follow-up, with a 92% finger oxygen saturation. A repeat chest computed tomography scan revealed scattered patchy ground-glass shadows in both lungs, which was consistent with alveolar protein deposition but with a lower density than in the radiograph from October 23, 2022. CONCLUSION: TBCB has unique advantages in diagnosing atypical alveolar protein deposition, particularly for enabling the early detection of PAP. This information can help patients take preventive measures to prevent or halt PAP development by avoiding dusty environments and seeking treatment with total lung lavage and inhaled granulocyte macrophage colony-stimulating factor. |
format | Online Article Text |
id | pubmed-10424030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-104240302023-08-15 Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report Jian, Li Zhao, Qi-Quan World J Clin Cases Case Report BACKGROUND: Pulmonary alveolar proteinosis (PAP) often presents nonspecifically and can be easily confused with: (1) Idiopathic interstitial lung fibrosis; (2) alveolar carcinoma; (3) pulmonary tuberculosis; and (4) other lung diseases such as viral pneumonia, mycoplasma pneumonia, and chlamydial pneumonia. CASE SUMMARY: Diagnosis: In this case, a patient was diagnosed with PAP through transbronchial cryobiopsy (TBCB) and quantitative metagenomic next-generation sequencing, which confirmed the impairment of surfactant turnover as the underlying cause of PAP. Interventions: High-volume total lung lavage was performed for this patient. Outcomes: The patient's clinical condition had improved significantly by the 6-month follow-up, with a 92% finger oxygen saturation. A repeat chest computed tomography scan revealed scattered patchy ground-glass shadows in both lungs, which was consistent with alveolar protein deposition but with a lower density than in the radiograph from October 23, 2022. CONCLUSION: TBCB has unique advantages in diagnosing atypical alveolar protein deposition, particularly for enabling the early detection of PAP. This information can help patients take preventive measures to prevent or halt PAP development by avoiding dusty environments and seeking treatment with total lung lavage and inhaled granulocyte macrophage colony-stimulating factor. Baishideng Publishing Group Inc 2023-07-16 2023-07-16 /pmc/articles/PMC10424030/ /pubmed/37583994 http://dx.doi.org/10.12998/wjcc.v11.i20.4932 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Report Jian, Li Zhao, Qi-Quan Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report |
title | Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report |
title_full | Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report |
title_fullStr | Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report |
title_full_unstemmed | Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report |
title_short | Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report |
title_sort | unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424030/ https://www.ncbi.nlm.nih.gov/pubmed/37583994 http://dx.doi.org/10.12998/wjcc.v11.i20.4932 |
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