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Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery

BACKGROUND: Literature focused on cancer screening and management is lacking in the transgender population. AIM: To action to increase contributions to the scientific literature that drives the creation of cancer screening and management protocols for transgender and gender nonconforming (TGNC) pati...

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Autores principales: Panichella, Juliet C, Araya, Sthefano, Nannapaneni, Siddhartha, Robinson, Samuel G, You, Susan, Gubara, Sarah M, Gebreyesus, Maria T, Webster, Theresa, Patel, Sameer A, Hamidian Jahromi, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424092/
https://www.ncbi.nlm.nih.gov/pubmed/37583948
http://dx.doi.org/10.5306/wjco.v14.i7.265
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author Panichella, Juliet C
Araya, Sthefano
Nannapaneni, Siddhartha
Robinson, Samuel G
You, Susan
Gubara, Sarah M
Gebreyesus, Maria T
Webster, Theresa
Patel, Sameer A
Hamidian Jahromi, Alireza
author_facet Panichella, Juliet C
Araya, Sthefano
Nannapaneni, Siddhartha
Robinson, Samuel G
You, Susan
Gubara, Sarah M
Gebreyesus, Maria T
Webster, Theresa
Patel, Sameer A
Hamidian Jahromi, Alireza
author_sort Panichella, Juliet C
collection PubMed
description BACKGROUND: Literature focused on cancer screening and management is lacking in the transgender population. AIM: To action to increase contributions to the scientific literature that drives the creation of cancer screening and management protocols for transgender and gender nonconforming (TGNC) patients. METHODS: We performed a systematic search of PubMed on January 5(th), 2022, with the following terms: “TGNC”, OR “transgender”, OR “gender non-conforming”, OR “gender nonbinary” AND “cancer screening”, AND “breast cancer”, AND “cervical cancer”, AND “uterine cancer”, AND “ovarian cancer”, AND “prostate cancer”, AND “testicular cancer”, AND “surveillance”, AND “follow-up”, AND “management”. 70 unique publications were used. The findings are discussed under “Screening” and “Management” categories. RESULTS: Screening: Current cancer screening recommendations default to cis-gender protocols. However, long-term gender-affirming hormone therapy and loss to follow-up from the gender-specific specialties contribute to a higher risk for cancer development and possible delayed detection. The only known screening guidelines made specifically for this population are from the American College of Radiology for breast cancer. Management: Prior to undergoing Gender Affirmation Surgery (GAS), discussion should address cancer screening and management in the organs remaining in situ. Cancer treatment in this population requires consideration for chemotherapy, radiation, surgery and/or reconstruction. Modification of hormone therapy is decided on a case-by-case basis. The use of prophylactic vs aesthetic techniques in surgery is still debated. CONCLUSION: When assessing transgender individuals for GAS, a discussion on the future oncologic risk of the sex-specific organs remaining in situ is essential. Cancer management in this population requires a multidisciplinary approach while the care should be highly individualized with considerations to social, medical, surgical and gender affirming surgery related specifications. Special considerations have to be made during planning for GAS as surgery will alter the anatomy and may render the organ difficult to sample for screening purposes. A discussion with the patient regarding the oncologic risk of remaining organs is imperative prior to GAS. Other special considerations to screening such as the conscious or unconscious will to unassociated with their remaining organs is also a key point to address. We currently lack high quality studies pertinent to the cancer topic in the gender affirmation literature. Further research is required to ensure more comprehensive and individualized care for this population.
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spelling pubmed-104240922023-08-15 Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery Panichella, Juliet C Araya, Sthefano Nannapaneni, Siddhartha Robinson, Samuel G You, Susan Gubara, Sarah M Gebreyesus, Maria T Webster, Theresa Patel, Sameer A Hamidian Jahromi, Alireza World J Clin Oncol Systematic Reviews BACKGROUND: Literature focused on cancer screening and management is lacking in the transgender population. AIM: To action to increase contributions to the scientific literature that drives the creation of cancer screening and management protocols for transgender and gender nonconforming (TGNC) patients. METHODS: We performed a systematic search of PubMed on January 5(th), 2022, with the following terms: “TGNC”, OR “transgender”, OR “gender non-conforming”, OR “gender nonbinary” AND “cancer screening”, AND “breast cancer”, AND “cervical cancer”, AND “uterine cancer”, AND “ovarian cancer”, AND “prostate cancer”, AND “testicular cancer”, AND “surveillance”, AND “follow-up”, AND “management”. 70 unique publications were used. The findings are discussed under “Screening” and “Management” categories. RESULTS: Screening: Current cancer screening recommendations default to cis-gender protocols. However, long-term gender-affirming hormone therapy and loss to follow-up from the gender-specific specialties contribute to a higher risk for cancer development and possible delayed detection. The only known screening guidelines made specifically for this population are from the American College of Radiology for breast cancer. Management: Prior to undergoing Gender Affirmation Surgery (GAS), discussion should address cancer screening and management in the organs remaining in situ. Cancer treatment in this population requires consideration for chemotherapy, radiation, surgery and/or reconstruction. Modification of hormone therapy is decided on a case-by-case basis. The use of prophylactic vs aesthetic techniques in surgery is still debated. CONCLUSION: When assessing transgender individuals for GAS, a discussion on the future oncologic risk of the sex-specific organs remaining in situ is essential. Cancer management in this population requires a multidisciplinary approach while the care should be highly individualized with considerations to social, medical, surgical and gender affirming surgery related specifications. Special considerations have to be made during planning for GAS as surgery will alter the anatomy and may render the organ difficult to sample for screening purposes. A discussion with the patient regarding the oncologic risk of remaining organs is imperative prior to GAS. Other special considerations to screening such as the conscious or unconscious will to unassociated with their remaining organs is also a key point to address. We currently lack high quality studies pertinent to the cancer topic in the gender affirmation literature. Further research is required to ensure more comprehensive and individualized care for this population. Baishideng Publishing Group Inc 2023-07-24 2023-07-24 /pmc/articles/PMC10424092/ /pubmed/37583948 http://dx.doi.org/10.5306/wjco.v14.i7.265 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Systematic Reviews
Panichella, Juliet C
Araya, Sthefano
Nannapaneni, Siddhartha
Robinson, Samuel G
You, Susan
Gubara, Sarah M
Gebreyesus, Maria T
Webster, Theresa
Patel, Sameer A
Hamidian Jahromi, Alireza
Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery
title Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery
title_full Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery
title_fullStr Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery
title_full_unstemmed Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery
title_short Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery
title_sort cancer screening and management in the transgender population: review of literature and special considerations for gender affirmation surgery
topic Systematic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424092/
https://www.ncbi.nlm.nih.gov/pubmed/37583948
http://dx.doi.org/10.5306/wjco.v14.i7.265
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