Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates

[Image: see text] While STING agonists have proven to be effective preclinically as anti-tumor agents, these promising results have yet to be translated in the clinic. A STING agonist antibody–drug conjugate (ADC) could overcome current limitations by improving tumor accessibility, allowing for syst...

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Detalles Bibliográficos
Autores principales: Duvall, Jeremy R., Thomas, Joshua D., Bukhalid, Raghida A., Catcott, Kalli C., Bentley, Keith W., Collins, Scott D., Eitas, Timothy, Jones, Brian D., Kelleher, Eugene W., Lancaster, Kelly, Protopopova, Marina, Ray, Soumya S., Ter-Ovanesyan, Elena, Xu, Ling, Yang, Liping, Zurita, Jeffrey, Damelin, Marc, Toader, Dorin, Lowinger, Timothy B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424177/
https://www.ncbi.nlm.nih.gov/pubmed/37486969
http://dx.doi.org/10.1021/acs.jmedchem.3c00907

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