Site-specific Conjugation of 6 DOTA Chelators to a CA19-9-targeting scFv-Fc Antibody for Imaging and Therapy

[Image: see text] Antibodies conjugated with diagnostic/therapeutic radionuclides are attractive options for inoperable cancers lacking accurate imaging methods and effective therapeutics, such as pancreatic cancer. Hence, we have produced an antibody radionuclide conjugate termed TE-1132 comprising...

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Detalles Bibliográficos
Autores principales: Chen, Li-An, Yu, Yueh-Hsiang, Tian, Wei-Ting, Lin, Wei-Chen, Grauffel, Cédric, Wu, Chun-Yi, Chen, Chuan-Lin, Lim, Carmay, Chu, Hsing-Mao, Chang, Tse-Wen, Peng, Chi-Jiun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424180/
https://www.ncbi.nlm.nih.gov/pubmed/37462154
http://dx.doi.org/10.1021/acs.jmedchem.3c00753

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