Principles and Applications of CF(2)X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery

[Image: see text] As an orthogonal principle to the established (hetero)aryl halides, we herein highlight the usefulness of CF(2)X (X = Cl, Br, or I) moieties. Using tool compounds bearing CF(2)X moieties, we study their chemical/metabolic stability and their logP/solubility, as well as the role of...

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Detalles Bibliográficos
Autores principales: Vaas, Sebastian, Zimmermann, Markus O., Schollmeyer, Dieter, Stahlecker, Jason, Engelhardt, Marc U., Rheinganz, Janosch, Drotleff, Bernhard, Olfert, Matthias, Lämmerhofer, Michael, Kramer, Markus, Stehle, Thilo, Boeckler, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424184/
https://www.ncbi.nlm.nih.gov/pubmed/37487500
http://dx.doi.org/10.1021/acs.jmedchem.3c00634

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