5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5

[Image: see text] Jumonji-C domain-containing protein 5 (JMJD5) is a 2-oxoglutarate (2OG)-dependent oxygenase that plays important roles in development, circadian rhythm, and cancer through unclear mechanisms. JMJD5 has been reported to have activity as a histone protease, as an N(ε)-methyl lysine d...

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Detalles Bibliográficos
Autores principales: Brewitz, Lennart, Nakashima, Yu, Piasecka, Sonia K., Salah, Eidarus, Fletcher, Sally C., Tumber, Anthony, Corner, Thomas P., Kennedy, Tristan J., Fiorini, Giorgia, Thalhammer, Armin, Christensen, Kirsten E., Coleman, Mathew L., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424186/
https://www.ncbi.nlm.nih.gov/pubmed/37527664
http://dx.doi.org/10.1021/acs.jmedchem.3c01114

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