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A case of pulmonary tumor embolism syndrome with thrombus in transit

The incidence of pulmonary tumor embolism in patients with solid tumors is estimated to be between 3% and 26% yet is rarely diagnosed. In this case, a 74-year-old male with sarcomatoid variant of urothelial carcinoma and recently diagnosed left renal vein thrombus treated with low-molecular-weight-h...

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Detalles Bibliográficos
Autores principales: Fuher, Alexandra, de Boer, Esther, Hountras, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424200/
https://www.ncbi.nlm.nih.gov/pubmed/37583563
http://dx.doi.org/10.1016/j.rmcr.2023.101896
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author Fuher, Alexandra
de Boer, Esther
Hountras, Peter
author_facet Fuher, Alexandra
de Boer, Esther
Hountras, Peter
author_sort Fuher, Alexandra
collection PubMed
description The incidence of pulmonary tumor embolism in patients with solid tumors is estimated to be between 3% and 26% yet is rarely diagnosed. In this case, a 74-year-old male with sarcomatoid variant of urothelial carcinoma and recently diagnosed left renal vein thrombus treated with low-molecular-weight-heparin, presented to the emergency department with acute syncope and dyspnea. He was found to have CT imaging of segmental and subsegmental arterial filling defects, a right atrial filling defect concerning for thrombus in transit and was diagnosed with pulmonary tumor embolism syndrome. The patient was treated with aspiration thrombectomy, with pathology demonstrating sarcomatoid urothelial carcinoma cells. He was initiated on a combination of gemcitabine plus carboplatin to decrease the tumor burden. While pulmonary tumor embolism syndrome is associated with a poor prognosis, prompt diagnosis and initiation of cancer-specific therapies can significantly improve survival.
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spelling pubmed-104242002023-08-15 A case of pulmonary tumor embolism syndrome with thrombus in transit Fuher, Alexandra de Boer, Esther Hountras, Peter Respir Med Case Rep Case Report The incidence of pulmonary tumor embolism in patients with solid tumors is estimated to be between 3% and 26% yet is rarely diagnosed. In this case, a 74-year-old male with sarcomatoid variant of urothelial carcinoma and recently diagnosed left renal vein thrombus treated with low-molecular-weight-heparin, presented to the emergency department with acute syncope and dyspnea. He was found to have CT imaging of segmental and subsegmental arterial filling defects, a right atrial filling defect concerning for thrombus in transit and was diagnosed with pulmonary tumor embolism syndrome. The patient was treated with aspiration thrombectomy, with pathology demonstrating sarcomatoid urothelial carcinoma cells. He was initiated on a combination of gemcitabine plus carboplatin to decrease the tumor burden. While pulmonary tumor embolism syndrome is associated with a poor prognosis, prompt diagnosis and initiation of cancer-specific therapies can significantly improve survival. Elsevier 2023-07-20 /pmc/articles/PMC10424200/ /pubmed/37583563 http://dx.doi.org/10.1016/j.rmcr.2023.101896 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Fuher, Alexandra
de Boer, Esther
Hountras, Peter
A case of pulmonary tumor embolism syndrome with thrombus in transit
title A case of pulmonary tumor embolism syndrome with thrombus in transit
title_full A case of pulmonary tumor embolism syndrome with thrombus in transit
title_fullStr A case of pulmonary tumor embolism syndrome with thrombus in transit
title_full_unstemmed A case of pulmonary tumor embolism syndrome with thrombus in transit
title_short A case of pulmonary tumor embolism syndrome with thrombus in transit
title_sort case of pulmonary tumor embolism syndrome with thrombus in transit
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424200/
https://www.ncbi.nlm.nih.gov/pubmed/37583563
http://dx.doi.org/10.1016/j.rmcr.2023.101896
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