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Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan

This study aimed to investigate the antibacterial and cytotoxic activity of 03 medicinal plants, Calligonum polygonides, Farsetia hamiltonii, and Pulcaria crispa, from Cholistan desert, Pakistan. The active constituents of plants species were extracted in 05 different solvents and the extracts were...

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Autores principales: Ejaz, Samina, Nasim, Faiz-ul-Hassan, Abdullah, Iqra, Rashid, Samia, Ashraf, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424204/
https://www.ncbi.nlm.nih.gov/pubmed/37583872
http://dx.doi.org/10.1016/j.sjbs.2023.103750
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author Ejaz, Samina
Nasim, Faiz-ul-Hassan
Abdullah, Iqra
Rashid, Samia
Ashraf, Muhammad
author_facet Ejaz, Samina
Nasim, Faiz-ul-Hassan
Abdullah, Iqra
Rashid, Samia
Ashraf, Muhammad
author_sort Ejaz, Samina
collection PubMed
description This study aimed to investigate the antibacterial and cytotoxic activity of 03 medicinal plants, Calligonum polygonides, Farsetia hamiltonii, and Pulcaria crispa, from Cholistan desert, Pakistan. The active constituents of plants species were extracted in 05 different solvents and the extracts were tested against various bacterial strains and brine shrimps. Although all Calligonum polygonides’s extracts except chloroform were active against Staphylococcus aureus the most active was the acetone extract (21 ± 0.00 mm at 200 μg/disc) and activity was better than Caricef (p-value 0.03). While its water extract was more potent (18 ± 1.45 mm at 200 μg/disc) than Augmentin and Caricef (p-value < 0.005). The methanol extract’s activity (15 ± 0.39 mm in 200 μg/disc) was comparable to Fucidin against Proteus vulgaris (p-value > 0.99) and activity of diethyl ether extract against Escherichia coli (10 ± 1.16 mm in 200 μg/disc) was same as of Urixin (p-value 0.91). Farsetia hamiltonii’s acetone extract against Pseudomonas aeruginosa (10 ± 0.15 mm in 1 μg/disc) was more active than Augmentin Caricef and Cefotax (p-value < 0.02) and against Staphylococcus aureus (15 ± 1.15 mm in 200 μg/disc) activity was higher than Caricef (p-value 0.03). All Pulicaria crispa’s extracts except water extract were found active against Staphylococcus aureus. However, the diethyl ether extract was most effective (25 + 0.00 mm at 150 μg /disc) and activity was more than Augmentin, Oxy-tetracycline, Fucidin, Urixin, Ceftriaxone (p-value < 0.05). Although all extracts were exhibited cytotoxic activity, the Calligonum polygonides’s acetone extract (100%), Farsetia hamiltonii’s diethyl ether extract (90%) and Pulicaria crispa’s methanol extract (100%) were most active at 1000 μg/ml concentration. This study validated the medicinal significance of the studied plants and thus opens the way for their therapeutic applications.
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spelling pubmed-104242042023-08-15 Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan Ejaz, Samina Nasim, Faiz-ul-Hassan Abdullah, Iqra Rashid, Samia Ashraf, Muhammad Saudi J Biol Sci Original Article This study aimed to investigate the antibacterial and cytotoxic activity of 03 medicinal plants, Calligonum polygonides, Farsetia hamiltonii, and Pulcaria crispa, from Cholistan desert, Pakistan. The active constituents of plants species were extracted in 05 different solvents and the extracts were tested against various bacterial strains and brine shrimps. Although all Calligonum polygonides’s extracts except chloroform were active against Staphylococcus aureus the most active was the acetone extract (21 ± 0.00 mm at 200 μg/disc) and activity was better than Caricef (p-value 0.03). While its water extract was more potent (18 ± 1.45 mm at 200 μg/disc) than Augmentin and Caricef (p-value < 0.005). The methanol extract’s activity (15 ± 0.39 mm in 200 μg/disc) was comparable to Fucidin against Proteus vulgaris (p-value > 0.99) and activity of diethyl ether extract against Escherichia coli (10 ± 1.16 mm in 200 μg/disc) was same as of Urixin (p-value 0.91). Farsetia hamiltonii’s acetone extract against Pseudomonas aeruginosa (10 ± 0.15 mm in 1 μg/disc) was more active than Augmentin Caricef and Cefotax (p-value < 0.02) and against Staphylococcus aureus (15 ± 1.15 mm in 200 μg/disc) activity was higher than Caricef (p-value 0.03). All Pulicaria crispa’s extracts except water extract were found active against Staphylococcus aureus. However, the diethyl ether extract was most effective (25 + 0.00 mm at 150 μg /disc) and activity was more than Augmentin, Oxy-tetracycline, Fucidin, Urixin, Ceftriaxone (p-value < 0.05). Although all extracts were exhibited cytotoxic activity, the Calligonum polygonides’s acetone extract (100%), Farsetia hamiltonii’s diethyl ether extract (90%) and Pulicaria crispa’s methanol extract (100%) were most active at 1000 μg/ml concentration. This study validated the medicinal significance of the studied plants and thus opens the way for their therapeutic applications. Elsevier 2023-09 2023-07-28 /pmc/articles/PMC10424204/ /pubmed/37583872 http://dx.doi.org/10.1016/j.sjbs.2023.103750 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ejaz, Samina
Nasim, Faiz-ul-Hassan
Abdullah, Iqra
Rashid, Samia
Ashraf, Muhammad
Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan
title Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan
title_full Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan
title_fullStr Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan
title_full_unstemmed Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan
title_short Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan
title_sort analysis of antibacterial and cytotoxic potential of medicinal plants from cholistan desert, pakistan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424204/
https://www.ncbi.nlm.nih.gov/pubmed/37583872
http://dx.doi.org/10.1016/j.sjbs.2023.103750
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