Structural and spectroscopic characterization of RufO indicates a new biological role in rufomycin biosynthesis

Rufomycins constitute a class of cyclic heptapeptides isolated from actinomycetes. They are secondary metabolites that show promising treatment against Mycobacterium tuberculosis infections by inhibiting a novel drug target. Several nonproteinogenic amino acids are integrated into rufomycins, includ...

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Detalles Bibliográficos
Autores principales: Jordan, Stephanie, Li, Bingnan, Traore, Ephrahime, Wu, Yifei, Usai, Remigio, Liu, Aimin, Xie, Zhong-Ru, Wang, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424215/
https://www.ncbi.nlm.nih.gov/pubmed/37451485
http://dx.doi.org/10.1016/j.jbc.2023.105049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424215/
https://www.ncbi.nlm.nih.gov/pubmed/37451485
http://dx.doi.org/10.1016/j.jbc.2023.105049

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