Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity

[Image: see text] The Plasmodium falciparum aspartic protease plasmepsin X (PMX) is essential for the egress of invasive merozoite forms of the parasite. PMX has therefore emerged as a new potential antimalarial target. Building on peptidic amino alcohols originating from a phenotypic screening hit,...

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Detalles Bibliográficos
Autores principales: Kovada, Vadims, Withers-Martinez, Chrislaine, Bobrovs, Raitis, Ce̅rule, Hele̅na, Liepins, Edgars, Grinberga, Solveiga, Hackett, Fiona, Collins, Christine R., Kreicberga, Agrita, Jiménez-Díaz, María Belén, Angulo-Barturen, Iñigo, Rasina, Dace, Suna, Edgars, Jaudzems, Kristaps, Blackman, Michael J., Jirgensons, Aigars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424242/
https://www.ncbi.nlm.nih.gov/pubmed/37505188
http://dx.doi.org/10.1021/acs.jmedchem.3c00812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424242/
https://www.ncbi.nlm.nih.gov/pubmed/37505188
http://dx.doi.org/10.1021/acs.jmedchem.3c00812

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