A concise review on the role of MIR100HG in human disorders

MIR100HG is a long non‐coding RNA (lncRNA) encoded by a locus on chr11:122,028,203‐122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation...

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Autores principales: Ghafouri‐Fard, Soudeh, Harsij, Atefeh, Farahzadi, Hossein, Hussen, Bashdar Mahmud, Taheri, Mohammad, Mokhtari, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424294/
https://www.ncbi.nlm.nih.gov/pubmed/37487022
http://dx.doi.org/10.1111/jcmm.17875
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author Ghafouri‐Fard, Soudeh
Harsij, Atefeh
Farahzadi, Hossein
Hussen, Bashdar Mahmud
Taheri, Mohammad
Mokhtari, Majid
author_facet Ghafouri‐Fard, Soudeh
Harsij, Atefeh
Farahzadi, Hossein
Hussen, Bashdar Mahmud
Taheri, Mohammad
Mokhtari, Majid
author_sort Ghafouri‐Fard, Soudeh
collection PubMed
description MIR100HG is a long non‐coding RNA (lncRNA) encoded by a locus on chr11:122,028,203‐122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF‐β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.
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spelling pubmed-104242942023-08-15 A concise review on the role of MIR100HG in human disorders Ghafouri‐Fard, Soudeh Harsij, Atefeh Farahzadi, Hossein Hussen, Bashdar Mahmud Taheri, Mohammad Mokhtari, Majid J Cell Mol Med Reviews MIR100HG is a long non‐coding RNA (lncRNA) encoded by a locus on chr11:122,028,203‐122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF‐β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders. John Wiley and Sons Inc. 2023-07-24 /pmc/articles/PMC10424294/ /pubmed/37487022 http://dx.doi.org/10.1111/jcmm.17875 Text en © 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Ghafouri‐Fard, Soudeh
Harsij, Atefeh
Farahzadi, Hossein
Hussen, Bashdar Mahmud
Taheri, Mohammad
Mokhtari, Majid
A concise review on the role of MIR100HG in human disorders
title A concise review on the role of MIR100HG in human disorders
title_full A concise review on the role of MIR100HG in human disorders
title_fullStr A concise review on the role of MIR100HG in human disorders
title_full_unstemmed A concise review on the role of MIR100HG in human disorders
title_short A concise review on the role of MIR100HG in human disorders
title_sort concise review on the role of mir100hg in human disorders
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424294/
https://www.ncbi.nlm.nih.gov/pubmed/37487022
http://dx.doi.org/10.1111/jcmm.17875
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