Cargando…

Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010

BACKGROUND: To explore the association of low-level lead exposure with all-cause mortality and cardiovascular disease (CVD) mortality among hypertensive patients. METHODS: This cohort study enrolled 6453 adults with hypertension from the National Health and Nutrition Examination Survey 2003–2010 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Lili, Wang, Chaofan, Liu, Tao, Xuan, Haochen, Li, Xiaoqun, Shi, Xiangxiang, Dai, Feng, Chen, Junhong, Li, Dongye, Xu, Tongda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424362/
https://www.ncbi.nlm.nih.gov/pubmed/37574566
http://dx.doi.org/10.1186/s13690-023-01148-6
_version_ 1785089655468720128
author Wang, Lili
Wang, Chaofan
Liu, Tao
Xuan, Haochen
Li, Xiaoqun
Shi, Xiangxiang
Dai, Feng
Chen, Junhong
Li, Dongye
Xu, Tongda
author_facet Wang, Lili
Wang, Chaofan
Liu, Tao
Xuan, Haochen
Li, Xiaoqun
Shi, Xiangxiang
Dai, Feng
Chen, Junhong
Li, Dongye
Xu, Tongda
author_sort Wang, Lili
collection PubMed
description BACKGROUND: To explore the association of low-level lead exposure with all-cause mortality and cardiovascular disease (CVD) mortality among hypertensive patients. METHODS: This cohort study enrolled 6453 adults with hypertension from the National Health and Nutrition Examination Survey 2003–2010 and followed mortality information through December 31, 2019. The baseline population were divided into four groups based on quartiles of blood lead levels (Q1: < 1.2 μg/dL, Q2: 1.2–1.6 μg/dL, Q3: 1.7–2.4 μg/dL, Q4: 2.5–4.9 μg/dL). The correlation of blood lead levels to mortality was investigated by Kaplan–Meier survival curves, restricted cubic spline (RCS), proportional hazard regression model, and subgroup analysis. RESULTS: During a median follow-up period of 136 (interquartile range 113, 164) months, a total of 1943 (30.1%) deaths were documented, among which 553 (28.5%) were due to CVD. Blood lead showed a linear dose–response relationship with all-cause and CVD mortality. After adequate adjusting for confounders, the risk of all-cause death rose by 23% for each unit increase in continuous variable blood lead (hazard ratio (HR): 1.23; 95% confidence interval (CI):1.16–1.30). When blood lead was a quartile group variable, participants in the Q 4 group had a 73% higher risk of death than those in the Q 1 group (HR:1.73; 95% CI: 1.43–2.10; P for trend < 0.001). The association for CVD mortality was analogous. The concordant results were achieved in the subgroup analysis. CONCLUSION: Elevated blood lead levels were strongly associated with an increased all-cause and CVD mortality in adults with hypertension, even at the reference range of blood lead. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13690-023-01148-6.
format Online
Article
Text
id pubmed-10424362
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-104243622023-08-15 Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010 Wang, Lili Wang, Chaofan Liu, Tao Xuan, Haochen Li, Xiaoqun Shi, Xiangxiang Dai, Feng Chen, Junhong Li, Dongye Xu, Tongda Arch Public Health Research BACKGROUND: To explore the association of low-level lead exposure with all-cause mortality and cardiovascular disease (CVD) mortality among hypertensive patients. METHODS: This cohort study enrolled 6453 adults with hypertension from the National Health and Nutrition Examination Survey 2003–2010 and followed mortality information through December 31, 2019. The baseline population were divided into four groups based on quartiles of blood lead levels (Q1: < 1.2 μg/dL, Q2: 1.2–1.6 μg/dL, Q3: 1.7–2.4 μg/dL, Q4: 2.5–4.9 μg/dL). The correlation of blood lead levels to mortality was investigated by Kaplan–Meier survival curves, restricted cubic spline (RCS), proportional hazard regression model, and subgroup analysis. RESULTS: During a median follow-up period of 136 (interquartile range 113, 164) months, a total of 1943 (30.1%) deaths were documented, among which 553 (28.5%) were due to CVD. Blood lead showed a linear dose–response relationship with all-cause and CVD mortality. After adequate adjusting for confounders, the risk of all-cause death rose by 23% for each unit increase in continuous variable blood lead (hazard ratio (HR): 1.23; 95% confidence interval (CI):1.16–1.30). When blood lead was a quartile group variable, participants in the Q 4 group had a 73% higher risk of death than those in the Q 1 group (HR:1.73; 95% CI: 1.43–2.10; P for trend < 0.001). The association for CVD mortality was analogous. The concordant results were achieved in the subgroup analysis. CONCLUSION: Elevated blood lead levels were strongly associated with an increased all-cause and CVD mortality in adults with hypertension, even at the reference range of blood lead. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13690-023-01148-6. BioMed Central 2023-08-14 /pmc/articles/PMC10424362/ /pubmed/37574566 http://dx.doi.org/10.1186/s13690-023-01148-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Lili
Wang, Chaofan
Liu, Tao
Xuan, Haochen
Li, Xiaoqun
Shi, Xiangxiang
Dai, Feng
Chen, Junhong
Li, Dongye
Xu, Tongda
Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010
title Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010
title_full Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010
title_fullStr Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010
title_full_unstemmed Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010
title_short Association of low-level lead exposure with all-cause and cardiovascular disease mortality in US adults with hypertension: evidence from the National Health and Nutrition Examination Survey 2003–2010
title_sort association of low-level lead exposure with all-cause and cardiovascular disease mortality in us adults with hypertension: evidence from the national health and nutrition examination survey 2003–2010
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424362/
https://www.ncbi.nlm.nih.gov/pubmed/37574566
http://dx.doi.org/10.1186/s13690-023-01148-6
work_keys_str_mv AT wanglili associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010
AT wangchaofan associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010
AT liutao associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010
AT xuanhaochen associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010
AT lixiaoqun associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010
AT shixiangxiang associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010
AT daifeng associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010
AT chenjunhong associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010
AT lidongye associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010
AT xutongda associationoflowlevelleadexposurewithallcauseandcardiovasculardiseasemortalityinusadultswithhypertensionevidencefromthenationalhealthandnutritionexaminationsurvey20032010