Cargando…

Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer

BACKGROUND: N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely associated with a variety of cancers progression, including colorectal cancer (CRC). This study showed that activated lipid metabolism and glycolysis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Mujie, Chen, Jinhao, Lu, Feiyu, Zhao, Minghui, Wu, Suwen, Hu, Chunhua, Yu, Ping, Kan, Jingbao, Bai, Jianan, Tian, Ye, Tang, Qiyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424385/ https://www.ncbi.nlm.nih.gov/pubmed/37580808 http://dx.doi.org/10.1186/s13578-023-01100-9

Ejemplares similares

ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner
por: Chen, Jinhao, et al.
Publicado: (2023)

Novel insights into the interplay between m6A modification and programmed cell death in cancer
por: Chen, Jinhao, et al.
Publicado: (2023)

FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression
por: Ye, Mujie, et al.
Publicado: (2023)

m(6)A reader IGF2BP2-stabilized CASC9 accelerates glioblastoma aerobic glycolysis by enhancing HK2 mRNA stability
por: Liu, Hongjiang, et al.
Publicado: (2021)

FABP5 regulates lipid metabolism to facilitate pancreatic neuroendocrine neoplasms progression via FASN mediated Wnt/β‐catenin pathway
por: Lu, Feiyu, et al.
Publicado: (2023)

Gene Polymorphisms of m6A Erasers FTO and ALKBH1 Associated with Susceptibility to Gastric Cancer
por: Li, Yue, et al.
Publicado: (2022)

Methylmalonic acid promotes colorectal cancer progression via activation of Wnt/β-catenin pathway mediated epithelial–mesenchymal transition
por: Hu, Chunhua, et al.
Publicado: (2023)

Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5
por: Huang, Yue, et al.
Publicado: (2015)

The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis
por: Yuan, Yuan, et al.
Publicado: (2022)

Aerobic glycolysis enhances HBx-initiated hepatocellular carcinogenesis via NF-κBp65/HK2 signalling
por: Chen, Lingjun, et al.
Publicado: (2022)

Orlistat Induces Ferroptosis in Pancreatic Neuroendocrine Tumors by Inactivating the MAPK Pathway
por: Ye, Mujie, et al.
Publicado: (2023)

Decreased ALKBH5, FTO, and YTHDF2 in Peripheral Blood Are as Risk Factors for Rheumatoid Arthritis
por: Luo, Qing, et al.
Publicado: (2020)

Impact of m6A demethylase (ALKBH5, FTO) genetic polymorphism and expression levels on the development of pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

FAM201A encodes small protein NBASP to inhibit neuroblastoma progression via inactivating MAPK pathway mediated by FABP5
por: Ye, Mujie, et al.
Publicado: (2023)

Deciphering the mechanism of PSORI-CM02 in suppressing keratinocyte proliferation through the mTOR/HK2/glycolysis axis
por: Wang, Maojie, et al.
Publicado: (2023)

RNA demethylase ALKBH5 regulates hypopharyngeal squamous cell carcinoma ferroptosis by posttranscriptionally activating NFE2L2/NRF2 in an m(6)A‐IGF2BP2‐dependent manner
por: Ye, Jing, et al.
Publicado: (2022)

FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2
por: Sun, Meige, et al.
Publicado: (2022)

ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis
por: Yu, Hao, et al.
Publicado: (2020)

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer
por: Li, Yue, et al.
Publicado: (2019)

ALKBH5 promotes hypopharyngeal squamous cell carcinoma apoptosis by targeting TLR2 in a YTHDF1/IGF2BP2-mediated manner
por: Ye, Jing, et al.
Publicado: (2023)

Sevoflurane Inhibits lncRNA HOTAIR-Modulated Stability of HK2 mRNA in a m6A-Dependent Manner to Dampen Aerobic Glycolysis and Proliferation in Lung Cancer
por: Sun, Xuefeng, et al.
Publicado: (2022)

N(6)-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury
por: Xu, Kaiwei, et al.
Publicado: (2020)

ALKBH1-8 and FTO: Potential Therapeutic Targets and Prognostic Biomarkers in Lung Adenocarcinoma Pathogenesis
por: Wu, Geting, et al.
Publicado: (2021)

RNA-Seq data of ALKBH5 and FTO double knockout HEK293T human cells
por: Smolin, Egor A., et al.
Publicado: (2022)

Angelica sinensis Polysaccharide and Astragalus membranaceus Polysaccharide Accelerate Liver Regeneration by Enhanced Glycolysis via Activation of JAK2/STAT3/HK2 Pathway
por: Wen, Xu-Dong, et al.
Publicado: (2022)

Involvement of EZH2 in aerobic glycolysis of prostate cancer through miR-181b/HK2 axis
por: Tao, Tao, et al.
Publicado: (2017)

UBR7 inhibits HCC tumorigenesis by targeting Keap1/Nrf2/Bach1/HK2 and glycolysis
por: Zhao, Liang, et al.
Publicado: (2022)

ALKBH5‐induced circular RNA NRIP1 promotes glycolysis in thyroid cancer cells by targeting PKM2
por: Ji, Xiaoyu, et al.
Publicado: (2023)

WNT/β-catenin-suppressed FTO expression increases m(6)A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis
por: Yang, Xueying, et al.
Publicado: (2021)

MicroRNA-216b targets HK2 to potentiate autophagy and apoptosis of breast cancer cells via the mTOR signaling pathway
por: Liu, Ting, et al.
Publicado: (2021)

m(6)A demethylase ALKBH5 drives denervation‐induced muscle atrophy by targeting HDAC4 to activate FoxO3 signalling
por: Liu, Yuantong, et al.
Publicado: (2022)

N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
por: Zou, Shui, et al.
Publicado: (2016)

B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2
por: Shi, Tongguo, et al.
Publicado: (2019)

ALKBH5-mediated m(6)A mRNA methylation governs human embryonic stem cell cardiac commitment
por: Han, Zhenbo, et al.
Publicado: (2021)

LncRNA ALKBH3‐AS1 enhances ALKBH3 mRNA stability to promote hepatocellular carcinoma cell proliferation and invasion
por: Lu, Qiliang, et al.
Publicado: (2022)

ALKBH5-mediated m(6)A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability
por: Huang, Xin, et al.
Publicado: (2023)

TRIM46 activates AKT/HK2 signaling by modifying PHLPP2 ubiquitylation to promote glycolysis and chemoresistance of lung cancer cells
por: Tantai, Jicheng, et al.
Publicado: (2022)

Downregulation of MEG3 promotes neuroblastoma development through FOXO1-mediated autophagy and mTOR-mediated epithelial-mesenchymal transition
por: Ye, Mujie, et al.
Publicado: (2020)

Methylation‐associated silencing of miR‐9‐1 promotes nasopharyngeal carcinoma progression and glycolysis via HK2
por: Xu, Qian‐Lan, et al.
Publicado: (2021)

GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
por: Yu, Hongshuang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tkl0nve5utgme0vllrl0b5sg79