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Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer

BACKGROUND: N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely associated with a variety of cancers progression, including colorectal cancer (CRC). This study showed that activated lipid metabolism and glycolysis...

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Detalles Bibliográficos
Autores principales:	Ye, Mujie, Chen, Jinhao, Lu, Feiyu, Zhao, Minghui, Wu, Suwen, Hu, Chunhua, Yu, Ping, Kan, Jingbao, Bai, Jianan, Tian, Ye, Tang, Qiyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424385/ https://www.ncbi.nlm.nih.gov/pubmed/37580808 http://dx.doi.org/10.1186/s13578-023-01100-9

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