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Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction
Acute myocardial infarction has long been the leading cause of death in coronary heart disease, which is characterized by irreversible cardiomyocyte death and restricted blood supply. Conventional reperfusion therapy can further aggravate myocardial injury. Stem cell therapy, especially with mesench...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424417/ https://www.ncbi.nlm.nih.gov/pubmed/37580705 http://dx.doi.org/10.1186/s12964-023-01227-9 |
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author | Liu, Yuchang Wang, Minrui Yu, Yang Li, Chunhong Zhang, Chunxiang |
author_facet | Liu, Yuchang Wang, Minrui Yu, Yang Li, Chunhong Zhang, Chunxiang |
author_sort | Liu, Yuchang |
collection | PubMed |
description | Acute myocardial infarction has long been the leading cause of death in coronary heart disease, which is characterized by irreversible cardiomyocyte death and restricted blood supply. Conventional reperfusion therapy can further aggravate myocardial injury. Stem cell therapy, especially with mesenchymal stem cells (MSCs), has emerged as a promising approach to promote cardiac repair and improve cardiac function. MSCs may induce these effects by secreting exosomes containing therapeutically active RNA, proteins and lipids. Notably, normal cardiac function depends on intracardiac paracrine signaling via exosomes, and exosomes secreted by cardiac cells can partially reflect changes in the heart during disease, so analyzing these vesicles may provide valuable insights into the pathology of myocardial infarction as well as guide the development of new treatments. The present review examines how exosomes produced by MSCs and cardiac cells may influence injury after myocardial infarction and serve as therapies against such injury. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01227-9. |
format | Online Article Text |
id | pubmed-10424417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104244172023-08-15 Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction Liu, Yuchang Wang, Minrui Yu, Yang Li, Chunhong Zhang, Chunxiang Cell Commun Signal Review Acute myocardial infarction has long been the leading cause of death in coronary heart disease, which is characterized by irreversible cardiomyocyte death and restricted blood supply. Conventional reperfusion therapy can further aggravate myocardial injury. Stem cell therapy, especially with mesenchymal stem cells (MSCs), has emerged as a promising approach to promote cardiac repair and improve cardiac function. MSCs may induce these effects by secreting exosomes containing therapeutically active RNA, proteins and lipids. Notably, normal cardiac function depends on intracardiac paracrine signaling via exosomes, and exosomes secreted by cardiac cells can partially reflect changes in the heart during disease, so analyzing these vesicles may provide valuable insights into the pathology of myocardial infarction as well as guide the development of new treatments. The present review examines how exosomes produced by MSCs and cardiac cells may influence injury after myocardial infarction and serve as therapies against such injury. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01227-9. BioMed Central 2023-08-14 /pmc/articles/PMC10424417/ /pubmed/37580705 http://dx.doi.org/10.1186/s12964-023-01227-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Liu, Yuchang Wang, Minrui Yu, Yang Li, Chunhong Zhang, Chunxiang Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction |
title | Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction |
title_full | Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction |
title_fullStr | Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction |
title_full_unstemmed | Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction |
title_short | Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction |
title_sort | advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424417/ https://www.ncbi.nlm.nih.gov/pubmed/37580705 http://dx.doi.org/10.1186/s12964-023-01227-9 |
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