Cargando…

Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia

BACKGROUND: Promoting stem cell donation behaviors could be crucial in advancing stem cell-based treatment, research and improving public health in Saudi Arabia. Donation of stem cells can be considered an act of social welfare just like blood donation because stem-cell-based therapies are emerging...

Descripción completa

Detalles Bibliográficos
Autores principales: AL-Shammary, Asma Ayyed, Hassan, Sehar un-Nisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424454/
https://www.ncbi.nlm.nih.gov/pubmed/37574547
http://dx.doi.org/10.1186/s40780-023-00299-6
_version_ 1785089681857183744
author AL-Shammary, Asma Ayyed
Hassan, Sehar un-Nisa
author_facet AL-Shammary, Asma Ayyed
Hassan, Sehar un-Nisa
author_sort AL-Shammary, Asma Ayyed
collection PubMed
description BACKGROUND: Promoting stem cell donation behaviors could be crucial in advancing stem cell-based treatment, research and improving public health in Saudi Arabia. Donation of stem cells can be considered an act of social welfare just like blood donation because stem-cell-based therapies are emerging as a hope for those suffering from chronic health conditions and/or terminal illnesses. AIM: This study aims at assessing levels of awareness about sources of stem-cells, donor organizations and predictors of stem cell donation behavior in target population. METHODS: The study employed a cross-sectional online survey method. The study sample comprises 1325 educated Saudi people living in Ha’il city. The survey questionnaire collected data about respondents’ demographic background, awareness about various sources of stem cells and stem-cell donor registries, willingness to donate stem cells, registration status and obstacles in stem cell donation registration. Percentages, Chi-square analysis and Odd Ratios were computed to analyze the data. RESULTS: In this sample, (n = 696; 52%) were males and (n = 629; 48%) were females. Although (n = 1308; 98%) percent of respondents reported willingness to donate stem cell, less than one percent (n = 6; 0.5) were registered with Saudi Stem Cell Registry. Over 50% of respondents hold inaccurate perceptions about sources of stem cell. Odd Ratio (OR) values from binary logistic regression model identified four factors as significant predictors of non-registration status. These included (i) unaware about donor agencies and procedures (OR = 10.07; p < 0.05), (ii) unaware about possibility to donate stem cells (OR = 8.08; p < 0.05) (iii) concerns about impact on health (OR = 10.01; p < 0.05) and (iv) have health issues that does not permit donation (OR = 10.50; p < 0.05). CONCLUSION: Stem cell registrations can be enhanced through appropriate health education programs that focus on increasing awareness about donation procedures, trustworthy donor organizations and reducing people apprehensions related to donation.
format Online
Article
Text
id pubmed-10424454
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-104244542023-08-15 Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia AL-Shammary, Asma Ayyed Hassan, Sehar un-Nisa J Pharm Health Care Sci Research Article BACKGROUND: Promoting stem cell donation behaviors could be crucial in advancing stem cell-based treatment, research and improving public health in Saudi Arabia. Donation of stem cells can be considered an act of social welfare just like blood donation because stem-cell-based therapies are emerging as a hope for those suffering from chronic health conditions and/or terminal illnesses. AIM: This study aims at assessing levels of awareness about sources of stem-cells, donor organizations and predictors of stem cell donation behavior in target population. METHODS: The study employed a cross-sectional online survey method. The study sample comprises 1325 educated Saudi people living in Ha’il city. The survey questionnaire collected data about respondents’ demographic background, awareness about various sources of stem cells and stem-cell donor registries, willingness to donate stem cells, registration status and obstacles in stem cell donation registration. Percentages, Chi-square analysis and Odd Ratios were computed to analyze the data. RESULTS: In this sample, (n = 696; 52%) were males and (n = 629; 48%) were females. Although (n = 1308; 98%) percent of respondents reported willingness to donate stem cell, less than one percent (n = 6; 0.5) were registered with Saudi Stem Cell Registry. Over 50% of respondents hold inaccurate perceptions about sources of stem cell. Odd Ratio (OR) values from binary logistic regression model identified four factors as significant predictors of non-registration status. These included (i) unaware about donor agencies and procedures (OR = 10.07; p < 0.05), (ii) unaware about possibility to donate stem cells (OR = 8.08; p < 0.05) (iii) concerns about impact on health (OR = 10.01; p < 0.05) and (iv) have health issues that does not permit donation (OR = 10.50; p < 0.05). CONCLUSION: Stem cell registrations can be enhanced through appropriate health education programs that focus on increasing awareness about donation procedures, trustworthy donor organizations and reducing people apprehensions related to donation. BioMed Central 2023-08-14 /pmc/articles/PMC10424454/ /pubmed/37574547 http://dx.doi.org/10.1186/s40780-023-00299-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
AL-Shammary, Asma Ayyed
Hassan, Sehar un-Nisa
Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia
title Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia
title_full Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia
title_fullStr Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia
title_full_unstemmed Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia
title_short Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia
title_sort knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from ha’il city to track the prospects of regenerative medicine in saudi arabia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424454/
https://www.ncbi.nlm.nih.gov/pubmed/37574547
http://dx.doi.org/10.1186/s40780-023-00299-6
work_keys_str_mv AT alshammaryasmaayyed knowledgeaboutstemcellsourcesandobstaclesindonationofbonemarrowandperipheralbloodstemcellsacrosssectionalsurveyfromhailcitytotracktheprospectsofregenerativemedicineinsaudiarabia
AT hassanseharunnisa knowledgeaboutstemcellsourcesandobstaclesindonationofbonemarrowandperipheralbloodstemcellsacrosssectionalsurveyfromhailcitytotracktheprospectsofregenerativemedicineinsaudiarabia